中国实验动物学报2025，Vol.33Issue(10)：1539-1545,7.DOI:10.3969/j.issn.1005-4847.2025.10.015
斑马鱼模型在炎症性肠病中的应用及研究进展
Application and research progress in the use of zebrafish in inflammatory bowel disease research
摘要
Abstract
Inflammatory bowel disease(IBD)is a non-specific chronic inflammatory bowel condition.Crohn's disease(CD)and ulcerative colitis(UC)are the 2 main types of IBD.IBD is prone to recurrent attacks,which is associated with many factors,such as immune dysfunction,intestinal microenvironment homeostasis imbalance,and environmental and genetic factors;however,its specific pathogenesis is still unclear.Zebrafish has recently emerged as an emerging animal model and have been used extensively for mechanistic research into IBD,model construction,activity evaluation,and screening of anti-IBD agents,due to their unique biological advantages.Based on the latest research progress using zebrafish in the field of IBD,this review systematically introduces the intestinal development characteristics,tissue structure,intestinal immunity,IBD model,and the application of drug screening in zebrafish,to demonstrate the value of zebrafish in the study of IBD.关键词
斑马鱼/炎症性肠病/动物模型/药物筛选Key words
zebrafish/inflammatory bowel disease/animal model/drug screening分类
生物科学引用本文复制引用
徐丽艳,李方珍,王宇欣,靳梦,张云,刘可春,王荣春..斑马鱼模型在炎症性肠病中的应用及研究进展[J].中国实验动物学报,2025,33(10):1539-1545,7.基金项目
山东省科技型中小企业创新能力提升工程项目(2024TSGC0145,2023TSGC0242),山东省重点研发计划(2022CXGC020515).Funded by the Project for Enhancing the Innovation Capacity of Small and Medium-Sized Technological Enterprises in Shandong Province(2024TSGC0145,2023TSGC0242),Key R&D Program of Shandong Province(2022CXGC020515). （2024TSGC0145,2023TSGC0242）
