中国实验动物学报2025，Vol.33Issue(10)：1546-1558,13.DOI:10.3969/j.issn.1005-4847.2025.10.016
线粒体自噬在脑缺血损伤中的作用及中药调控机制研究进展
Role of mitophagy in cerebral ischemic injury and research progress on the regulatory mechanism of traditional Chinese medicine
摘要
Abstract
Mitochondrial autophagy is an important mechanism for maintaining cellular homeostasis,closely related to the occurrence and development of cerebral ischemic injury,and is an important way of neuronal death.In recent years,a large number of experimental studies have confirmed that traditional Chinese medicine has a significant effect on treating cerebral ischemic injury.Its advantages of multi-target,multi pathway,low toxicity and high efficiency have become an important component of the treatment of cerebral ischemic injury.Traditional Chinese medicine formulas and monomeric active ingredients such as Xiaoxuming decoction,Zishen Huoxue formula,flavonoids,alkaloids,etc.can regulate mitochondrial autophagy related signaling pathways and targets,inhibit neuronal autophagic death,alleviate pathological damage to brain tissue,and exert neuroprotective effects.This article analyzes the molecular mechanism of traditional Chinese medicine regulating mitochondrial autophagy in the treatment of cerebral ischemic injury from four aspects:an overview of mitochondrial autophagy,related signaling pathways,its relationship with cerebral ischemic injury,and the regulatory effects of traditional Chinese medicine.The aim is to provide ideas and references for future basic research and clinical treatment.关键词
线粒体自噬/脑缺血损伤/信号通路/中医药/机制研究Key words
mitophagy/cerebral ischemic injury/signal pathway/traditional chinese medicine/mechanism research分类
生物科学引用本文复制引用
周盼盼,杨潼,王姝瑞,崔应麟..线粒体自噬在脑缺血损伤中的作用及中药调控机制研究进展[J].中国实验动物学报,2025,33(10):1546-1558,13.基金项目
河南省中医药科学研究专项课题(2023ZY1007),国家中医药管理局2022年第二届全国名中医传承工作室建设项目(2100601).Funded by Special Project of Traditional Chinese Medicine Science Research in Henan Province(2023ZY1007),the Second National Famous Traditional Chinese Medicine Inheritance Studio Construction Project of the State Administration of Traditional Chinese Medicine in 2022(2100601). （2023ZY1007）
