中国实用外科杂志2025，Vol.45Issue(10)：1186-1190,5.DOI:10.19538/j.cjps.issn1005-2208.2025.10.22
肝细胞癌综合治疗研究进展
Research progress on comprehensive treatment of hepatocellular carcinoma
摘要
Abstract
Hepatocellular carcinoma(HCC)is one of the major malignancies under intensive control efforts in China,with a five-year survival rate remains to be improved.Early diagnosis and stage-guided comprehensive management are key measures to improve prognosis.For early-stage patients,curative surgery remains the primary approach to achieving long-term survival,while postoperative adjuvant therapies are increasingly moving toward precision and individualization.For intermediate and advanced stages,emphasis has shifted to conversion therapy and the combined use of locoregional and systemic treatments.In recent years,the rapid advancement of systemic therapies has significantly improved survival in advanced HCC and reshaped the therapeutic landscape.At present,treatment paradigm for advanced HCC has gradually evolved toward immunotherapy-based combination regimens.Overall,comprehensive management of HCC is trending toward"precision in locoregional therapy,earlier application of systemic therapy,and individualized full-course management".Within the multidisciplinary team framework,individualized strategies that integrate tumor stage,molecular characteristics,and patient condition are of critical importance for further improving survival outcomes.关键词
肝细胞癌/生存/综合治疗/免疫治疗/靶向治疗/多学科综合治疗协作组Key words
hepatocellular carcinoma/survival/comprehen-sive treatment/immunotherapy/targeted therapy/multi-disci-plinary team分类
医药卫生引用本文复制引用
张维志,刘连新..肝细胞癌综合治疗研究进展[J].中国实用外科杂志,2025,45(10):1186-1190,5.基金项目
National Natural Science Foundation of China(No.82373232) （No.82373232）
Anhui Province Key Research and Development Plan(No.202204295107020025) （No.202204295107020025）
The First Affiliated Hospital of University of Science and Technology of China Innovation Research Team Project(No.CXGG01) 国家自然科学基金项目(No.82373232) （No.CXGG01）
安徽省重点研究与开发计划项目(No.202204295107020025) （No.202204295107020025）
中国科学技术大学附属第一医院创新攻关团队项目(No.CXGG01) （No.CXGG01）
