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血清壳多糖酶3样蛋白1水平对乙型肝炎病毒相关肝细胞癌的辅助诊断价值

林子義蒋燕霁林秋伶韦小夏周子寒马莹莹林标扬余红平梁秀妹

中国癌症防治杂志2025，Vol.17Issue(5)：582-589,8.

中国癌症防治杂志2025，Vol.17Issue(5)：582-589,8.DOI:10.3969/j.issn.1674-5671.2025.05.09

血清壳多糖酶3样蛋白1水平对乙型肝炎病毒相关肝细胞癌的辅助诊断价值

Auxiliary diagnostic value of serum chitinase-3-like protein 1 levels in hepatitis B virus-related hepatocellular carcinoma

林子義 ¹蒋燕霁 ²林秋伶 ¹韦小夏 ¹周子寒 ³马莹莹 ⁴林标扬 ⁵余红平 ⁶梁秀妹⁷

作者信息

1. 530021 南宁广西医科大学附属肿瘤医院临床研究部
2. 广西医科大学附属肿瘤医院伦理委员会办公室
3. 广西医科大学附属肿瘤医院肿瘤防控办公室
4. 310058 杭州浙江大学浙江加州国际纳米枝术研究院
5. 310058 杭州浙江大学浙江加州国际纳米枝术研究院||98195美国西雅图华盛顿大学医学院
6. 530021 南宁广西医科大学附属肿瘤医院实验研究部||区域性高发肿瘤早期防治研究教育部重点实验室(广西医科大学)||广西区域性高发肿瘤早期防治研究重点实验室||广西壮族自治区卫生健康委员会肿瘤分子医学重点(培育)实验室(广西医科大学附属肿瘤医院)||广西壮族自治区肿瘤分子医学工程研究中心
7. 广西医科大学附属肿瘤医院疾病流程管理办公室
折叠

摘要

Abstract

Objective To investigate the auxiliary diagnostic value of serum chitinase-3-like protein 1(CHI3L1)in hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC).Methods A total of 654 patients with HBV-related HCC,408 patients with chronic hepatitis B(CHB),and 551 apparently healthy individuals(AHC)were enrolled.The levels of serum CHI3L1,alpha-fetoprotein(AFP),alpha-fetoprotein variant L3(AFP-L3),and des-γ-carboxy prothrombin prothrombin(DCP)were quantified.Receiver operating charac-teristic(ROC)curves were plotted.The sensitivity,specificity,and area under the curve(AUC)were used to determine the anxiliary diagnostic value of each serum biomarker in identifying HBV-related HCC.Results The levels of serum CHI3L1(156.16 ng/mL),AFP(125.29 ng/mL),AFP-L3(14.96 ng/mL),and DCP(359.75 ng/mL)were significantly elevated in the HCC group compared to the CHB and AHC groups(all P＜0.001).In the context of auxiliary diagnosis for HBV-related HCC,early-stage HCC,and small HCC using in-dividual biomarkers,AFP yielded the highest AUC among the four biomarkers.Nevertheless,the diagnostic efficacy was significantly improved when AFP combined with AFP-L3,DCP,and CHI3L1.For HBV-related HCC patients who are AFP-negative(＜20 ng/mL),the supplementary diagnostic efficacy of the combination of CHI3L1 and DCP(AHC control group:AUC=0.938;CHB control group:AUC=0.878)outperformed individual biomarkers(AHC control group:CHI3L1 AUC=0.888,DCP AUC=0.763;CHB control group:CHI3L1 AUC=0.769,DCP AUC=0.789).Conclusions The integration of CHI3L1 and commonly clinical biomarkers(AFP,AFP-L3,DCP)can significantly enhances the auxiliary diagnostic efficacy for HBV-related HCC,with particularly demonstrating critical value for early-stage HCC,small HCC,and AFP-negative cases.

关键词

壳多糖酶3样蛋白1/肝细胞癌/小肝癌/乙型肝炎病毒/甲胎蛋白

Key words

Chitinase-3-like protein 1/Hepatocellular carcinoma/Small hepatocellular carcinoma/Hepatitis B virus/Alpha fetoprotein

分类

医药卫生

引用本文复制引用

林子義,蒋燕霁,林秋伶,韦小夏,周子寒,马莹莹,林标扬,余红平,梁秀妹..血清壳多糖酶3样蛋白1水平对乙型肝炎病毒相关肝细胞癌的辅助诊断价值[J].中国癌症防治杂志,2025,17(5):582-589,8.

基金项目

广西医疗卫生适宜技术开发与推广应用项目(S2022112 （）

S2021022) （）

国家重点研发计划资助项目(2022YFA1303801) （2022YFA1303801）

中国癌症防治杂志

ISSN：1674-5671

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