中国实用内科杂志2025，Vol.45Issue(11)：952-956,5.DOI:10.19538/j.nk2025110108
血清单胺氧化酶及炎症标志物与冠状动脉病变严重程度相关性研究
Study on the correlation of serum monoamine oxidase and inflammatory markers with the severity of coronary artery lesions
摘要
Abstract
Objective To investigate the correlation of monoamine oxidase(MAO),monocyte-to-lymphocyte ratio(MLR),neutrophil-to-lymphocyte ratio(NLR)and neutrophil-to-high-density lipoprotein ratio(NHR)with coronary heart disease(CHD),and to explore whether they are associated with the severity of coronary artery lesions.Methods Totally 617 patients who underwent coronary angiography in the Department of Cardiovascular Medicine of Shengjing Hospital Affiliated to China Medical University from July 2022 to December 2023 were included,and they were divided into two groups:451 cases in the CHD group and 166 cases in the non-CHD group.Differences in MAO,MLR,NLR,and NHR were compared between the two groups.The CHD group was further divided according to the Gensini scoring standard.The correlation between Gensini score and MAO,MLR,NLR,NHR was analyzed to assess their relationship with the severity of coronary artery lesions.Results Patients in the CHD group had higher levels of MAO,MLR,NLR,and NHR than those in the non-CHD group,with statistically significant differences(P＜0.05).Binary logistic regression analysis was conducted on the statistically significant indicators of the two groups,and the results showed that the two indicators had statistical differences:MLR(OR=1.05,95％CI 1.03-1.07,P＜0.001),and MAO(OR=1.70,95％CI 1.48-1.94,P＜0.001).Among the groups divided by different Gensini scores,the group with the highest score had higher NHR(4.97)and MAO(6.10 U/L)than the group with the lowest score[NHR(4.07),MAO(5.09 U/L)],and the difference was statistically significant(P＜0.05).Conclusion MLR and MAO have certain predictive value for the occurrence of CHD.Among groups with different Gensini scores,NHR and MAO are associated with the severity of coronary artery lesions.关键词
冠心病/炎症反应/单胺氧化酶/单核细胞与淋巴细胞的比值/中性粒细胞与淋巴细胞的比值/中性粒细胞与高密度脂蛋白胆固醇的比值/Gensini评分Key words
coronary heart disease/inflammatory reaction/monoamine oxidase/ratio of monocytes to lymphocytes/ratio of neutrophils to lymphocytes/ratio of neutrophils to high-density lipoprotein/Gensini score分类
医药卫生引用本文复制引用
赵晓童,曹乾..血清单胺氧化酶及炎症标志物与冠状动脉病变严重程度相关性研究[J].中国实用内科杂志,2025,45(11):952-956,5.基金项目
辽宁省科技计划联合计划(应用基础研究项目)(2023JH2/101700199) （应用基础研究项目）
