中国药业2025，Vol.34Issue(23)：42-45,4.DOI:10.3969/j.issn.1006-4931.2025.23.010
咳喘药学服务门诊药学服务用于慢性阻塞性肺疾病急性加重期效果分析
Application Effect of Pharmaceutical Care Based on Cough and Wheeze Pharmaceutical Care Clinic in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
摘要
Abstract
Objective To investigate the application effect of pharmaceutical care based on cough and wheeze pharmaceutical care clinic(CWPC)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A retrospective analysis was conducted on the medical records of 120 AECOPD patients admitted to the Pulmonary and Critical Care Medicine Department of the hospital from June to December 2023.The patients were divided into the control group(received medication education from general outpatient physicians)and the intervention group(received medication education from visiting pharmacists in CWPC),with 60 cases in each group.The clinical efficacy,clinical symptoms,lung function,serum levels of interleukin-6(IL-6),interleukin-8(IL-8),high-sensitivity C-reactive protein(hs-CRP),and incidence of adverse reactions between the two groups were compared.Results The total effective rate in the intervention group was 95.00%,which was significantly higher than 81.67%in the control group(P<0.05).After the intervention,the scores of the modified version of the Medical Research Council Respiratory(mMRC)questionnaire and COPD Self-Assessment Test(CAT)questionnaire in the two groups significantly decreased(P<0.05),and those in the intervention group were significantly lower than those in the control group(P<0.05);the forced vital capacity(FVC),forced expiratory volume in one second(FEV1),percentage of FEV1 to FVC(FEV1/FVC%),and percentage of FEV1 to predicted value(FEV1%pred)in the two groups significantly increased(P<0.05),and those in the intervention group were significantly higher than those in the control group(P<0.05);the serum levels of IL-6,IL-8,and hs-CRP in the two groups significantly decreased(P<0.05),and those in the intervention group were significantly lower than those in the control group(P<0.05).During the treatment,the incidence of adverse reactions was comparable between the intervention group and the control group(8.33%vs.11.67%,P>0.05).Conclusion Compared to the Pulmonary and Critical Care Medicine Department,the CWPC can better leverage the advantages of pharmacists in providing pharmaceutical care to improve the clinical efficacy,symptoms,and medication safety of AECOPD patients.关键词
咳喘药学服务门诊/慢性阻塞性肺疾病急性加重期/药学服务/治疗效果Key words
cough and wheeze pharmaceutical care clinic/acute exacerbation of chronic obstructive pulmonary disease/pharmaceutical care/therapeutic effect分类
医药卫生引用本文复制引用
于小杰,王娜..咳喘药学服务门诊药学服务用于慢性阻塞性肺疾病急性加重期效果分析[J].中国药业,2025,34(23):42-45,4.基金项目
河北省秦皇岛市科学技术研究与发展计划项目[201902A210]. （）
