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Dampness syndrome aggravates T helper 17/regulatory T imbalance to promote renal injury in rats with experimental membranous nephropathy

SHAN Wenjun GU Haowen GUAN Haiyu LI Ping WANG Yi HAN Miaoru WANG Houchun HUANG Xiaoyan BAO Kun

中医杂志(英文版)2025,Vol.45Issue(5):1028-1039,12.
中医杂志(英文版)2025,Vol.45Issue(5):1028-1039,12.DOI:10.19852/j.cnki.jtcm.2025.05.009

Dampness syndrome aggravates T helper 17/regulatory T imbalance to promote renal injury in rats with experimental membranous nephropathy

Dampness syndrome aggravates T helper 17/regulatory T imbalance to promote renal injury in rats with experimental membranous nephropathy

SHAN Wenjun 1GU Haowen 1GUAN Haiyu 1LI Ping 2WANG Yi 1HAN Miaoru 1WANG Houchun 1HUANG Xiaoyan 3BAO Kun2

作者信息

  • 1. Guangzhou University of Chinese Medicine,Guangzhou 510145,China
  • 2. State Key Laboratory of Dampness Syndrome of Chinese Medicine,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510006,China||Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research,Guangzhou 510006,China||Nephrology Department,Guangdong Provincial Hospital of Chinese Medicine,Guangzhou 510006,China||Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Disease,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510006,China
  • 3. State Key Laboratory of Dampness Syndrome of Chinese Medicine,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510006,China||Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research,Guangzhou 510006,China||Nephrology Department,Guangdong Provincial Hospital of Chinese Medicine,Guangzhou 510006,China
  • 折叠

摘要

关键词

glomerulonephritis,membranous/Th17 cells/T-lymphocytes,regulatory/dampness syndrome

Key words

glomerulonephritis,membranous/Th17 cells/T-lymphocytes,regulatory/dampness syndrome

引用本文复制引用

SHAN Wenjun,GU Haowen,GUAN Haiyu,LI Ping,WANG Yi,HAN Miaoru,WANG Houchun,HUANG Xiaoyan,BAO Kun..Dampness syndrome aggravates T helper 17/regulatory T imbalance to promote renal injury in rats with experimental membranous nephropathy[J].中医杂志(英文版),2025,45(5):1028-1039,12.

基金项目

Supported by the Special Project of State Key Laboratory of Dampness Syndrome of Chinese Medicine:a Randomized Controlled Clinical Study of Sanqi Qushi Granules in the Treatment of Membranous Nephropathy(No.SZ2021ZZ36) (No.SZ2021ZZ36)

a Cohort Study on the Pathogenesis and Evolution of Dampness Syndrome in Idiopathic Membranous Nephropathy and Its Material Basis(No.SZ2021ZZ09) (No.SZ2021ZZ09)

the National Natural Science Foundation of China:Research on the Role of Damp Nephropathy based on the Metabolic Disorders-T helper 17/Regulatory T Imbalance Evil in the Progression of Membranous(No.81974565) (No.81974565)

the Guangzhou Science and Technology Plan Project:Exploring the Mechanism of Treating Membranous Nephropathy based on Dampness from the Perspective of Regulating Amino Acid Metabolism Disorders(No.2023A03J0746) (No.2023A03J0746)

Multi-omics Study to Explore the Material Basis of Dampness Syndrome in Membranous Nephropathy and the Intervention Mechanism of Sanqi Qushi Decoction(No.2024A03J0117) (No.2024A03J0117)

a Multimodal Machine Learning Prediction Model based on Pathological Images,Transcriptomics and Traditional Chinese Medicine Syndromes to Explore the Prognosis-related lncRNA Molecules of Membranous Nephropathy and the Intervention Mechanism of Sanqi Qushi Decoction(No.2025A03J4062) (No.2025A03J4062)

Research Project of Guangdong Provincial Hospital of Traditional Chinese Medicine:Construction of a Risk Management Prediction Model for Membranous Nephropathy Based on Artificial Intelligence Technology(No.YN2023HL03) (No.YN2023HL03)

Study on the Pathogenesis Evolution and Microbiological Mechanism of Membranous Nephropathy with Dampness Syndrome Based on the Changes of Tongue Coating Microecology(No.YN2023MB10) (No.YN2023MB10)

Post-doctoral Research Project of Guangdong Provincial Hospital of Chinese Medicine:Study on the Mechanism of Yinyang Shengmai Method in Regulating Myocardial Infarction in Diabetic Rats based on Ang/Vascular Endothelial Growth Factor-Mediated Angiogenesis(No.10814) (No.10814)

Funding Project of Guangdong Provincial Administration of Traditional Chinese Medicine:Study on the Mechanism of"Dampness Stagnation in Blood Collaterals"inducing Vascular Aging Based on Oxidative Stress-inflammation Crosstalk and Intervention of Traditional Chinese Medicine(No.20233021) (No.20233021)

China Postdoctoral Science Foundation Funded Project:Study on the Mechanism of Shenmai Injection in Promoting Angiogenesis after Myocardial Infarction in Rats with Qi and Yin Deficiency Type Diabetic Nephropathy(No.2023M730810) (No.2023M730810)

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