中山大学学报（自然科学版）（中英文）2025，Vol.64Issue(6)：7-15,9.DOI:10.13471/j.cnki.acta.snus.ZR20250037
新会青柑皮中辛弗林含量及其健康风险评估
Synephrine quantification and health risk assessment of Xinhui Qinggan peel
摘要
Abstract
Xinhui Qinggan Tea is a novel beverage produced from near-mature fruits of Xinhui(Guangdong,China)Citrus reticulata'Chachi',commonly known as"Qinggan",in which the pulp is removed and filled with tea.Its distinctive blend of fruity and tea aromas has made it particularly popular among consumers.The peel of Qinggan contains alkaloids,particularly synephrine,which is known for its therapeutic properties including vasoconstriction,brochodilation,blood pressure elevation,pupil dilation and smooth muscle stimulation.However,potential health risks associated with long-term intake of synephrine from Qinggan peel,including adverse reactions,have remained a matter of concern.To this end,this study aimed to determinate the content of synephrine of Xinhui Qinggan peel and comprehensively evaluate their safety concern as well as its processed tea products.We have established a validated quantitative methodology and determined the content of synephrine in 26 batches of Xinhui Qinggan peel samples,45 batches of Xinhui Qinggan tea rind(without tea)samples,and 20 batches of Guangchenpi(the authentic medicinal material for Citri Reticulatae Pericarpium)samples.Based on the determination of synephrine,we further performed the health risk assessments for synephrine exposure in consumers of different ages and both genders by using the Monte Carlo simulation.The results showed that the Hazard Quotient(HQ)values for the Reasonable Maximum Exposure risk(RME risk)of synephrine exposure from Xinhui Qinggan peel and Xinhui Qinggan tea rind were below 0.02 across all groups,significantly lower than the USEPA safety threshold(HQ<1).Overall,our results indicated that daily consumption of Xinhui Qinggan peel and Guangchenpi poses no significant health risks.关键词
新会青柑/辛弗林/含量测定/健康风险评估/Monte-Carlo模拟Key words
Xinhui near-mature Citrus reticulata'Chachi'(Qinggan)/synephrine/determination/health risk assessment/Monte-Carlo simulation分类
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廖彦,苏畅,吴灏,余振兴,曾嘉琳,彭维,苏薇薇,潘华金,王冰,王淑红,谢诗婷..新会青柑皮中辛弗林含量及其健康风险评估[J].中山大学学报（自然科学版）（中英文）,2025,64(6):7-15,9.基金项目
"十四五"广东省农业科技创新九大主攻方向专项(2023SDZG07) （2023SDZG07）
广东省乡村振兴战略专项项目(2024KJ22) （2024KJ22）
