摘要
Abstract
Objective:To explore the clinical application value of a predictive model based on shear wave elastography(SWE)and multiple parameters in the risk stratification of esophageal and gastric varices(EGV)in patients with liver cirrhosis.Methods:A total of 72 patients with liver cirrhosis were enrolled.Using the gastroscopy results as the gold standard,all patients were divided into 2 groups,the non/mild EGV group(34 cases)and the moderate/severe EGV group(38 cases).The liver stiffness measurement(LSM),spleen stiffness measurement(SSM),portal vein diameter(PVD),portal vein velocity(PVV),splenic vein diameter(SVD),splenic vein velocity(SVV),spleen thickness,platelet,prothrombin time(PT),prothrombin activity(PTA),international normalized ratio(INR),total bilirubin,albumin,and Child-Pugh classification were compared between the two groups.The binary logistic regression analysis was used to screen for independent influencing factors of the severity of EGV and to construct a predictive model.ROC curve was plotted to evaluate the predictive efficacy of this model.Results:The differences in LSM,SSM,PVD,PVV,SVD,SVV,spleen thickness,platelet,PT,PTA,INR,total bilirubin,albumin and Child-Pugh classification between the two groups were all statistically significant(all P<0.05).Logistic regression analysis showed that SSM,spleen thickness and albumin were independent influencing factors for the severity of EGF in liver cirrhosis(all P<0.05).SSM,spleen thickness,albumin and platelet were included in the prediction model.ROC curve analysis showed that the AUCs for predicting the EGV occurrence were 0.899 for SSM,0.842 for spleen thickness,0.839 for platelet,0.796 for albumin,and 0.959 for the predictive model,and the predictive model demonstrated the best diagnostic efficacy.Conclusion:The predictive model based on SWE and multiple parameters shows good diagnostic efficacy in predicting the risk of EGV in patients with liver cirrhosis,providing an important reference for clinical treatment decisions.关键词
肝硬化/食管胃底静脉曲张/剪切波弹性成像/超声检查Key words
Cirrhosis/Esophageal and gastric varices/Shear wave elastography/Ultrasonography
