中国中西医结合影像学杂志2025，Vol.23Issue(6)：698-704,7.DOI:10.3969/j.issn.1672-0512.2025.06.006
基于fMRI针刺治疗阈下抑郁的脑效应机制研究
Brain mechanisms underlying acupuncture effects on subthreshold depression based on fMRI
摘要
Abstract
Objective:To explore the clinical efficacy and functional brain mechanisms of acupuncture and non-acupoint needling for treating subthreshold depression(SD).Methods:Twenty patients with SD were enrolled as SD group,and they were randomly assigned into a acupuncture group(10 cases)and a non-acupoint needling group(10 cases).and 10 healthy volunteers were enrolled as a control group.For the patients in the SD group,Hamilton Depression Scale-17(HAMD-17),Patient Health Questionnaire-9(PHQ-9),Short Form 12-item Health Survey-Version 2(SF-12V2)and Generalized Anxiety Disorder-7(GAD-7)scores were collected at baseline,the 4th and 8th weeks,meanwhile the cranial fMRI data were collected at baseline and the 8th week.For the control group,the scale scores and cranial fMRI data were collected only at enrollment.Results:At the 4th week,the acupuncture group exhibited significant decreases in HAMD-17,PHQ-9,and GAD-7 scores,along with significant increases in PCS and MSC scores from SF-12V2 scores(all P<0.05),compared with before acupuncture,and further improvements were observed at the 8th week(all P<0.05).In the 4th and 8th weeks of the non-acupoint needling group,the scores of HAMD-17,PHQ-9,PCS,MCS and GAD-7 showed no statistically significant differences compared with those before treatment(all P>0.05).The acupuncture group demonstrated superior improvement compared to the non-acupoint needling group,at the 4th week,there were more significant reductions in HAMD-17,PHQ-9 and GAD-7 scores and an increase in MCS score(all P<0.05),and no significant difference in PCS score(P>0.05).Meanwhile at the 8th week,more significant reductions in HAMD-17,PHQ-9,and GAD-7 scores were noted,along with more pronounced increases in PCS and MCS scores(all P<0.05).Compared with the control group,SD subjects exhibited elevated amplitude of low-frequency fluctuation(ALFF)values in the right sub-frontal gyrus of the insula(P<0.05)and decreased ALFF values in the right angular gyrus,left supplementary motor area and left precuneus(all P<0.05)before treatment.After treatment for 8 weeks,the acupuncture group exhibited decreased ALFF values in the right medial superior frontal gyrus(P<0.05)and increased functional connectivity in the cortex surrounding the left calcarine fissure(P<0.05).Moreover,the ALFF value in the right medial superior frontal gyrus was positively correlated with reductions in HAMD-17 scores(r=0.446,P<0.05).Conclusion:Acupuncture can improve clinical symptoms in SD,potentially by regulating cerebral function in the right medial superior frontal gyrus and cortical regions around the left calcarine fissure.关键词
阈下抑郁/针刺/随机对照试验/磁共振成像/非穴浅刺Key words
Subthreshold depression/Acupuncture/Randomized controlled trial/Magnetic resonance imaging/Non-acupoint shadow needling引用本文复制引用
陈浩宇,仙晋,张昕,于慧娟,朱双印,谭奇纹..基于fMRI针刺治疗阈下抑郁的脑效应机制研究[J].中国中西医结合影像学杂志,2025,23(6):698-704,7.基金项目
山东省自然科学基金青年科学基金项目(ZR2022QH197). （ZR2022QH197）
