中国中西医结合影像学杂志2025，Vol.23Issue(6)：705-710,716,7.DOI:10.3969/j.issn.1672-0512.2025.06.007
基于fMRI对经皮耳穴迷走神经刺激减重的中枢机制研究
Mechanism of transcutaneous auricular point vagus nerve stimulation in assisting weight loss based on fMRI
摘要
Abstract
Objective:To investigate the effects and mechanisms of transcutaneous auricular point vagus nerve stimulation(tapVNS)on weight loss.Methods:A total of 49 overweight and obese patients were recruited and randomly assigned to either the taVNS group(24 cases)or the control group(25 cases).The two groups were instructed to follow an energy-restricted diet and exercise regularly,while the tapVNS group received tapVNS treatment additionally.Weight,BMI,body composition analysis and resting-state fMRI data were collected before and after intervention.Results:A total of 38 participants completed the study,with 19 cases in each group.After intervention,the body weight,BMI,body fat,body fat rate and visceral fat index in the tapVNS group were lower than those before intervention,meanwhile the changes in body weight,BMI,body fat before and after intervention were greater than those in the control group,and the differences were statistically significant(all P<0.05).Compared with before intervention,the ALFF values of the right middle frontal gyrus,left supramarginal gyrus and left angular gyrus were decreased,and the ALFF value of the left middle temporal gyrus was increased in the tapVNS group.However,in the control group,the ALFF values increased in the left supramargonal gyrus and angular gyrus,and decreased in the right middle frontal gyrus,left middle temporal gyrus and right superior frontal gyrus(all P<0.05).Using the left middle temporal gyrus as the seed point,the functional connectivity of the medial superior frontal gyrus was decreased in the tapVNS group after intervention(cluster P<0.05,GRF corrected).Correlation analysis showed that the change of ALFF value in the left middle temporal gyrus before and after intervention was negatively correlated with the change of visceral fat index in the tapVNS group(r=-0.54,P=0.016).Conclusions:The adjuvant therapy of tapVNS demonstrates enhanced efficacy in promoting weight loss,with the middle temporal gyrus identified as a potential central target mediating its therapeutic effects.The underlying mechanisms may be attributed to its involvement in emotion regulation and stress relief.关键词
耳穴/迷走神经刺激/肥胖/磁共振成像Key words
Auricular Point/Vagus nerve stimulation/Obesity/Magnetic resonance imaging引用本文复制引用
张成锋,范文菲,汪慧青,谢长才,夏汪洋,谢焱钊,陈俊..基于fMRI对经皮耳穴迷走神经刺激减重的中枢机制研究[J].中国中西医结合影像学杂志,2025,23(6):705-710,716,7.基金项目
省部共建中医湿证国家重点实验室专项(SZ2022KF14) （SZ2022KF14）
省部共建中医湿证国家重点实验室专项(SZ2021ZZ08). （SZ2021ZZ08）
