重庆医学2025，Vol.54Issue(11)：2497-2502,6.DOI:10.3969/j.issn.1671-8348.2025.11.004
康北高原地区空洞型肺结核与免疫和营养状态的关系及预测模型构建
Correlation between pulmonary cavitary tuberculosis and immune and nutritional status and prediction model construction in the Kangbei Plateau
摘要
Abstract
Objective To investigate the association between cavitary pulmonary tuberculosis and im-munonutritional status in the Kangbei Plateau and construct a prediction model.Methods A total of 121 pa-tients with active pulmonary tuberculosis treated at Ganzi County People's Hospital from June 2023 to June 2024 were retrospectively enrolled and divided into cavitary group(n=53)and non-cavitary group(n=68)based on imaging findings.Clinical and laboratory data were collected.Influencing factors for pulmonary cavi-tation in tuberculosis were screened using univariate and multivariate logistic regression analysis to construct a prediction model.The model's performance was evaluated using receiver operating characteristic(ROC)curve analysis and the Hosmer-Lemeshow test.Results The cavitary group had higher proportions of smokers,spu-tum-positive cases,patients with disease duration>6 months,and patients with respiratory symptoms at ini-tial diagnosis,as well as higher neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),neutrophil count,and platelet count than the non-cavitary group(P<0.05).Conversely,the prognostic nutri-tional index(PNI),lymphocyte count,and albumin(ALB)level were lower in the cavitary group(P<0.05).Multivariate analysis identified disease duration,NLR,and ALB as influencing factors for pulmonary cavitation in tuberculosis patients(P<0.05).The prediction model yielded an area under the curve(AUC)of 0.909,and the Hosmer-Lemeshow test indicated good model fit(χ2=10.740,P=0.217).Conclusion Pulmonary cavitation in high-altitude tuberculosis patients is associated with disease duration,ALB,and NLR.The com-bined predictive value of these three indicators is high.关键词
肺结核/空洞/免疫/营养/高海拔Key words
tuberculosis/cavity/immunity/nutrition/high altitude分类
医药卫生引用本文复制引用
凤婧,韩娟,李继琼,尼玛降村,扎西拉姆,徐忠碧,胡晓波..康北高原地区空洞型肺结核与免疫和营养状态的关系及预测模型构建[J].重庆医学,2025,54(11):2497-2502,6.基金项目
成都市卫生健康委员会科研课题(2025359) （2025359）
成都市科技局重点研发支撑计划(2024-YF09-00021-SN) （2024-YF09-00021-SN）
甘孜县人民医院基层卫生事业研究课题(2025GZX002). （2025GZX002）
