重庆医学2025，Vol.54Issue(11)：2509-2514,6.DOI:10.3969/j.issn.1671-8348.2025.11.006
早期肠内营养干预对结直肠癌术后患者康复的影响
Effect of early enteral nutrition intervention on postoperative recovery in colorectal cancer patients
摘要
Abstract
Objective To investigate the effects of early enteral nutrition intervention on nutritional sta-tus and immune function in postoperative colorectal cancer patients.Methods Sixty-two patients undergoing laparoscopic radical resection of colorectal cancer in this hospital from July 2022 to December 2024 were se-lected as subjects and divided into an observation group and a control group using the random number table method,with 31 cases in each group.The observation group received sequential administration of warm water,glucose,and whole-protein nutrition combined with probiotics starting 6 hours postoperatively.The control group was given parenteral nutrition as the main form,supplemented with enteral nutrition as needed.Nutri-tional indicators,immune indicators,intestinal function,and short-term clinical outcomes during hospitaliza-tion were compared between the two groups.Results On postoperative days 3 and 5,the levels of prealbumin(PA),albumin(ALB),transferrin(TRF),and retinol-binding protein(RBP)in the observation group were significantly higher than those in the control group(P<0.05).On postoperative day 5,the NRS2002 score in the observation group was significantly lower than that in the control group(P<0.05).Additionally,on post-operative day 5 and week 2,the reduction in patient body weight was significantly lower in the observation group compared to the control group(P<0.05).On postoperative day 5,CD4,CD8,CD4/CD8 ratio,IgA,and IgG levels were significantly higher,while CRP level was significantly lower in the observation group than in the control group,and the Karnofsky score was significantly higher(P<0.05).The first flatus and defecation times were significantly earlier in the observation group compared to the control group,and the length of hos-pital stay and cost were significantly reduced in the observation group,while patient satisfaction was signifi-cantly higher(P<0.05).Conclusion Early enteral nutrition intervention can effectively improve the nutri-tional status and immune function of patients following colorectal cancer surgery,promote the recovery of in-testinal function,and attenuate stress response.关键词
结直肠癌/腹腔镜/肠内营养/益生菌/免疫Key words
colorectal cancer/laparoscopy/enteral nutrition/probiotics/immunity分类
医药卫生引用本文复制引用
王本泉,项本宏,张毅,方兴贵..早期肠内营养干预对结直肠癌术后患者康复的影响[J].重庆医学,2025,54(11):2509-2514,6.基金项目
芜湖市科技局重点研发与成果转化项目(2023yf099). （2023yf099）
