摘要
Abstract
Objective To evaluate the relationship between ultrasound-derived fat fraction(UDFF)and non-contrast multislice helieal computed tomography(MSCT)CT values,aiming to estimate hepatic fat content using UDFF.Methods A total of 140 patients from Beijing Tsinghua Changgung Hospital were prospectively enrolled between February 2024 AND June 2024.Based on the order of admission,the first 110 patients were assigned to the training set and the subsequent 30 patients to the validation set.All patients underwent both ultrasonography and upper abdominal MSCT within 7 days.The training set was categorized into a normal group(hepatic fat content<5.0%,n=68),a mild fatty liver group(hepatic fat content≥5.0%and<10.0%,n=30),and a moderate-to-severe fatty liver group(hepatic fat content≥10.0%,n=12).UDFF and CT values were measured in the right hepatic lobe using regions of interest(ROI)analysis.Correlation between UDFF and CT values was assessed,and comparisons were made among different fatty liver groups.Diagnostic performance of UDFF was evaluated using ROC curve analysis.Results In the training set,UDFF showed a strong negative correlation with CT values(r=-0.738,P<0.001),with statistically significant differences among groups(P<0.001).The UDFF values in the moderate-to-severe fatty liver group were significantly higher than those in the mild fatty liver and normal groups and normal groups(P<0.001).For diagnosing mild fatty liver,the area under the curve(AUC)was 0.661(P=0.011、95%CI:0.536～0.785),with a sensitivity of 43.3%,specificity of 85.3%,and a cutoff value of 6.1%.For moderate-to-severe fatty liver,the AUC was 0.921(P<0.001、95%CI:0.809～1.032),with a sensitivity of 91.7%,specificity of 93.3%,and a cutoff value of 10.4%.In the validation set,UDFF demonstrated an accuracy of 71.4%,sensitivity of 57.1%,specificity of 76.2%for mild fatty liver diagnosis,and an accuracy of 88.9%,sensitivity of 100%,specificity of 85.7%for moderate-to-severe fatty liver diagnosis.Conclusion UDFF exhibits a strong negative correlation with CT values in the quantitative diagnosis of fatty liver,and demonstrates high accuracy in diagnosing moderate-to-severe fatty liver.关键词
超声/计算机断层扫描/超声衍生脂肪分数/脂肪肝Key words
ultrasonography/CT/ultrasound-derived fat fraction/fatty liver
