分子影像学杂志2025，Vol.48Issue(11)：1410-1414,5.DOI:10.12122/j.issn.1674-4500.2025.11.14
平衡期对比增强CT测定细胞外体积分数在胃癌术前病理学分级中的预测价值
The predictive value of extracellular volume fraction measured by contrast-enhanced CT in preoperative pathological grading of gastric cancer
李莉 1丁伟伟 1黄雪莹 1毛静 1马喜玲1
作者信息
- 1. 宁夏医科大学总医院放射科,宁夏 银川 750001
- 折叠
摘要
Abstract
Objective To investigate whether the extracellular volume fraction(ECV)determined using enhanced computed tomography(CT)can predict the pathologic grade of gastric cancer.Methods A total of 50 patients with gastric cancer who underwent surgery and were pathologically confirmed at Ningxia Medical University General Hospital from January 2023 to October 2024,and who had undergone enhanced CT scans before surgery,were analyzed.The plain,arterial,venous,and balance phase values were recorded,and the absolute contrast-enhanced CT differences ΔS1=HUarterial phase-HUnormal scan,ΔS2=HU venous phase-HUnormal scan,ΔS3=HUequilibrium phase-HUnormal scan were obtained.The ECV of the primary lesion was calculated by measuring the CT values of the regions of interest in the plain and balance phases.Patients were allocated to either a low-grade or a high-grade group based on the histologic grading standard for gastric cancer(World Health Organization 2022 edition).The differences in the parameters between the two groups were evaluated for statistical significance.ROC curve was used to evaluate the diagnostic efficiency.Results The mean age of the 50 patients included[17 patients in the high-grade group(34.0%)and 33 patients in the low-grade group(66.0%)]had an average age of 62.54 years.There were significant differences between arterial stage(P=0.002),ΔS1(P=0.002),ΔS3(P=0.017),ECV(P<0.001)and pathological grade.The ROC curve demonstrated that the best efficacy in evaluating the pathologic grade of gastric cancer was achieved by ECV,with an area under the curve of 0.785(95%CI:0.646-0.924).The diagnostic threshold was 29.1%,sensitivity was 94.1%,and specificity was 36.4%.Conclusion The use of enhanced CT to obtain ECV is helpful in predicting the pathologic grade of gastric cancer.关键词
增强计算机断层扫描/细胞外体积分数/胃癌/病理分级Key words
enhanced computed tomography/extracellular volume fraction/gastric cancer/pathological grade引用本文复制引用
李莉,丁伟伟,黄雪莹,毛静,马喜玲..平衡期对比增强CT测定细胞外体积分数在胃癌术前病理学分级中的预测价值[J].分子影像学杂志,2025,48(11):1410-1414,5.
