高等学校化学学报2025，Vol.46Issue(12)：37-45,9.DOI:10.7503/cjcu20250187
除草剂烯草酮关键中间体的连续化合成工艺
Continuous Synthesis Process of Key Intermediates for the Herbicide Clethodim
摘要
Abstract
Clethodim,known for its high efficacy,low toxicity,broad herbicidal spectrum,extended application window and safety to subsequent crops,has become a representative cyclohexenone herbicide.5-[2-(Ethylthio)propyl]-2-propionyl-3-hydroxy-2-cyclohexen-1-one(abbreviated as Jing-Santong),a key intermediate of clethodim,faces challenges in traditional batch synthesis,such as low reaction efficiency and high energy consumption.This study developed a continuous-flow microchannel technology for the critical synthesis steps.By optimizing the cyclization and hydrolysis processes,the reaction time was reduced from 90 min to 4.8 min,achieving a 65.2%yield and 95.2%purity.The novel process significantly improves reaction efficiency and product quality,offering a promising approach for the industrial production of clethodim.关键词
除草剂/烯草酮/微通道连续流技术/合成工艺Key words
Herbicide/Clethodim/Microchannel continuous flow technology/Synthesis process分类
化学化工引用本文复制引用
任世伦,黄城,陈见爱,李蜜蜜,马景瑞,袁其亮,谭成侠..除草剂烯草酮关键中间体的连续化合成工艺[J].高等学校化学学报,2025,46(12):37-45,9.基金项目
一帆生物科技集团股份有限公司资助项目(批准号:KYY-HX-20240994). Supported by the Programe of Yifan Bio-Tech Group Co.Ltd.,China(No.KYY-HX-20240994). （批准号:KYY-HX-20240994）
