高等学校化学学报2025，Vol.46Issue(12)：46-54,9.DOI:10.7503/cjcu20250186
糠酸莫米松的溶剂合物和多晶型研究
Study on Solvates and Polymorphs of Mometasone Furoate
摘要
Abstract
Mometasone furoate(MF)is a potent synthetic corticosteroid widely used in the treatment of asthma,skin inflammation and pruritic diseases.This study discovered six solvates of MF(acetonitrile,methanol,acetone,dichloromethane,ethyl acetate and tetrahydrofuran solvates),and the crystal structure of the acetonitrile solvate and dichloromethane solvate were successfully resolved using single-crystal X-ray diffraction.Crystal structure analysis showed that the acetonitrile solvate belongs to the same P212121 space group as the known Form 1,but its PXRD pattern differs significantly.The dichloromethane solvate belongs to a new space group different from the anhydrous Form 1 and the hydrate.The MF molecule has an irregular shape with two large rotatable groups,which can form large cavity structures with adjustable sizes during crystal packing,enabling it to accommodate solvent molecules of different sizes and thus form various solvates.The stability of the solvates under different environments and their polymorphic transformations were studied by PXRD.The solvates of dichloromethane,acetonitrile,and ethyl acetate were unstable at room temperature,spontaneously desolvating and converting into a new metastable form,while the solvates of tetrahydrofuran,acetone,and methanol were relatively stable at room temperature.All these solvates and the new metastable forms converted to Form 1 upon heating.关键词
糠酸莫米松/多晶型/溶剂合物Key words
Mometasone furoate/Polymorph/Solvate分类
化学化工引用本文复制引用
王怡璇,刘奇,周蕾,蔡保理,王学重,何运良..糠酸莫米松的溶剂合物和多晶型研究[J].高等学校化学学报,2025,46(12):46-54,9.基金项目
北京市教育委员会项目(批准号:2201982100)和北京市自然科学基金(批准号:IS23033)资助. Supported by the Foundation of Beijing Municipal Education Commission,China(No.22019821001)and the Beijing Natural Science Foundation,China(No.IS23033). （批准号:2201982100）
