西部中医药2025，Vol.38Issue(11)：34-40,7.DOI:10.12174/j.issn.2096-9600.2025.11.07
基于数据挖掘和网络药理学探讨叶天士治疗痢疾用药规律
Ye Tianshi's Medication Rule for the Treatment of Dysentery Based on Data Mining and Network Pharmacology
摘要
Abstract
Objective:To primarily investigate the therapeutic mechanisms underlying prescriptions used in the treatment of dysentery through unearthing Ye Tianshi's medication rule for the disease,and exploring the main active ingredients of the core drug combinations contained in the prescription.Methods:TCMISS was adopted to establish the data base after collecting herbal prescriptions for dysentery in Ye Tianshi's book,the medication rule was analyzed through improved mutual information method,complex system entropy clustering,and unsupervised entropy hierarchical clustering,TCMSP and STRING Cytoscape were utilized to analyze drug-to-disease interactions,and to perform GO and KEGG enrichment analysis of the core drug combinations.Results:The study conducted data analysis of 121 selected prescriptions,confirmed four Qi and five flavors,the frequency of meridian tropism,medication frequency of the herbs in the prescriptions,and yielded 24 drug combinations.Association rule analysis identified"Huangqin(scutellariae radix)-Huanglian(coptidis rhizoma)"as the drug combination with the highest confidence,a total of 192 target genes were identified,while 5,836 target genes were found in dysentery-related diseases,163 common target genes were obtained through pairwise matching,the targets including AKT1,IL-6,VEGFA and CASP3 played an important role in the treatment of dysentery with the drug combination via Cytoscape;GO enrichment analysis yielded 166 entries,mainly involving the biological functions such as the activity of transcription factor,enzyme and receptor,KEGG pathway enrichment analysis contained 166 entries,principally regulating the pathways of human cytomegalovirus and Kaposi's sarcoma-associated herpesvirus infection,inflammation and cancer.Conclusion:Ye Tianshi's treatment for dysentery adopts differentiating cold and heat,deficiency and excess,tonification and purgation in combination,using cold and heat together,clearing heat and resolving dampness,regulating Qi,harmonizing blood and removing the stagnation as the general principles of medication via TCMISS.Ye Tianshi's medication has the characteristics of multi-component,multi-target and multi-pathway through network pharmacology analysis,and the core drug combina-tions exert the function by adjusting CMV infection,IL-17,TNF and other immune-related pathways,and it could provide the new idea for further treatment of the corresponding diseases of dysentery,which has laid the foundation for in-depth study on the mechanism of the prescriptions and medicines.关键词
数据挖掘/痢疾/叶天士/网络药理学Key words
data mining/dysentery/Ye Tianshi/network pharmacology分类
医药卫生引用本文复制引用
张培培,杨欣,梁国强,王萌,徐心怡,孙宏文..基于数据挖掘和网络药理学探讨叶天士治疗痢疾用药规律[J].西部中医药,2025,38(11):34-40,7.基金项目
江苏省自然科学基金面上项目(BK20201179). （BK20201179）
