四川大学学报（医学版）2025，Vol.56Issue(5)：1243-1250,8.DOI:10.12182/20250960203
生物膜相关院内感染的新型消毒技术研究进展
Advances in Novel Disinfection Technologies for Biofilm-Associated Nosocomial Infections
摘要
Abstract
The elimination of biofilms is a crucial step in controlling hospital-acquired infections.Once biofilms colonize luminal instruments,it is difficult to remove them using traditional disinfection methods.Conventional disinfection approaches now face a series of challenges,including microbial resistance,corrosiveness,cytotoxicity,residual disinfection byproducts,and environmental pollution.Therefore,developing novel disinfection technologies specifically targeting biofilm removal is vitally important.New disinfection technologies,such as slightly acidic electrolyzed water,plasma technology,surface modification techniques,nanomaterial-based disinfection,bacteriophage disinfection,and enzymatic disinfection,are constantly emerging.These technologies exhibit excellent performance against biofilms by leveraging the synergistic effects of multiple mechanisms,including the reactive oxygen species(ROS)burst,photocatalytic oxidation,physical disruption,and biological targeting.This review summarizes the characteristics,underlying mechanisms,and potential application scenarios of these novel disinfection technologies,with a particular focus on their effects against biofilms formed by common pathogenic bacteria on surfaces in hospital settings.It aims to provide a reference basis for the practical application and translation of these disinfection technologies and the development of new disinfection strategies.关键词
生物膜/化学消毒技术/物理消毒技术/生物消毒技术/综述Key words
Biofilm/Chemical disinfection technology/Physical disinfection technology/Biological disinfection technology/Review引用本文复制引用
可东卉,谭惺妍,陈坤,薛旭,安妮,叶珂睿,张晓蕊,李雨庆,曾菊梅..生物膜相关院内感染的新型消毒技术研究进展[J].四川大学学报（医学版）,2025,56(5):1243-1250,8.基金项目
成都市科技局重点研发支撑计划(No.2024-YF05-00039-SN)资助 （No.2024-YF05-00039-SN）
