杭州师范大学学报（自然科学版）2025，Vol.24Issue(6)：561-570,10.DOI:10.19926/j.cnki.issn.1674-232X.2024.07.151
温敏原位凝胶在不同给药途径中的应用进展
Progress on the Application of Thermosensitive in situ Gel in Various Administration Routes
摘要
Abstract
Thermosensitive in situ gel is a hydrogel with a three-dimensional network structure that undergoes phase transitions in response to the change of temperature or stimuli in external environment.Drug delivery systems based on thermosensitive in situ gels enable intelligent drug loading as well as site-specific,timed,and quantifiable controlled release,demonstrating significant application potential and research value.This article reviewed the common preparation materials,drug release mechanisms,and characteristics of thermosensitive in situ gels,with a focus on their applications across multiple administration routes,including intranasal,vaginal,periodontal,intratumoral injection,intra-articular injection,and ocular administration.关键词
温敏原位凝胶/药物递送/给药途径/控释Key words
thermosensitive in situ gel/drug delivery/administration routes/controlled release分类
医药卫生引用本文复制引用
张梓怡,沈奇英..温敏原位凝胶在不同给药途径中的应用进展[J].杭州师范大学学报（自然科学版）,2025,24(6):561-570,10.基金项目
浙江省基础公益研究计划项目(LGF20H300005) （LGF20H300005）
浙江省医药卫生科技计划一般项目(2024KY236) （2024KY236）
国家级大学生创新创业训练计划项目(202410346025) （202410346025）
杭州师范大学星光计划项目(2024XG0433). （2024XG0433）
