家畜生态学报2025，Vol.46Issue(11)：21-27,7.DOI:10.3969/j.issn.1673-1182.2025.11.004
东湖杂交羊CCSER1基因多态性与泌乳性状的关联分析
Association Analysis Between the Polymorphism of CCSER1 Gene and Lactation Traits in East Friesian and Hu Crossbred Sheep
摘要
Abstract
To investigate the effect of coiled-coil serine-rich protein 1(CCSER1)gene polymorphisms on the lactation performance of Donghu hybrid sheep,a total of 453 Donghu hybrid dairy ewes were select-ed as the research population.Single nucleotide polymorphisms(SNP)in the exon regions of the CCSER1 gene were detected,and their associations with milk yield,milk fat percentage,lactose percentage,and milk protein percentage were analyzed.The results showed that seven exon mutation sites were identified,all exhibiting low to moderate polymorphism,including three synonymous and four missense mutations.Among these sites,the wild-type alleles were predominant,with frequencies of wild homozygotes ranging from 0.870 to 0.946,heterozygotes from 0.103 to 0.243,and mutant homozygotes from 0 to 0.009.Associ-ation analysis revealed that individuals with the heterozygous AG genotype at the g.35014032A＞G locus had significantly higher milk fat percentage and total solids content than those with the AA genotype(P＜0.05).In conclusion,the g.35014032A＞G locus of the CCSER1 gene significantly affects milk quality traits and may serve as a potential molecular marker for improving milk quality in breeding programs,pro-viding both theoretical and practical value for the genetic selection of Donghu hybrid sheep.关键词
东湖杂交羊/泌乳性状/CCSER1/SNPKey words
East Friesian and Hu crossbred sheep/lactation traits/CSSER1/SNP分类
农业科技引用本文复制引用
张希云,陈星卓,李扬华,张磊,宋宇轩..东湖杂交羊CCSER1基因多态性与泌乳性状的关联分析[J].家畜生态学报,2025,46(11):21-27,7.基金项目
杨凌示范区科技计划项目(2024NY-05) （2024NY-05）
陕西省中央引导地方科技发展资金项目(2024ZY-CGZY-20) （2024ZY-CGZY-20）
陕西省自由探索类基础研究(2024ZY-JCYJ-02-06) （2024ZY-JCYJ-02-06）
