家畜生态学报2025，Vol.46Issue(11)：28-34,7.DOI:10.3969/j.issn.1673-1182.2025.11.005
威宁牛全基因组STR的遗传多样性和群体遗传学研究
Genetic Diversity and Population Genetics of Whole-genome STR in Weining Cattle
摘要
Abstract
This study aims to elucidate the genetic diversity,structure and differentiation of Weining cattle using whole-genome sequencing(WGS)focused on STR variations,and provides new genetic in-sights crucial for their conservation and development.Herein,WGS data from 18 Weining cattle and 50 samples from other reference cattle populations were utilized for a comprehensive genome-wide STR scan,and analyzed through various bioinformatics methods.The results indicated that(1)a total of 120 018 STR loci were identified in the Weining cattle genome,with most located in intergenic and intronic regions.No-tably,trinucleotide STRs exhibited the highest AGC content among them.(2)The average expected het-erozygosity of Weining cattle is 0.298,lower than Hainan cattle(0.335),higher than European cattle(0.162),and Northeast Asian cattle(0.202).(3)Phylogenetic trees and PCA based on STRs place Wein-ing cattle between taurine and indicine groups.(4)The genetic differentiation analysis of Weining and H ainan cattle based on STRs revealed differences in genes associated with growth(SOX5,CA 10),meat quality(PRKG1,MAST 4),reproductive performance(KIF17,GALNT13),and environmental adapta-bility(KHDRBS2,LEF1),highlighting the unique adaptability of Weining cattle to high-altitude cold environments.关键词
威宁牛/STR/全基因组/遗传多样性/群体遗传学Key words
weining cattle/STR/whole-genome/genetic diversity/population genetics分类
农业科技引用本文复制引用
马金萍,汪鹏飞,王明进,安兴红,雷初朝,吴道义..威宁牛全基因组STR的遗传多样性和群体遗传学研究[J].家畜生态学报,2025,46(11):28-34,7.基金项目
贵州省科技计划项目([2021]12-03号) （[2021]12-03号）
农业农村部国家肉牛牦牛产业技术体系毕节试验站(CARS-37) （CARS-37）
贵州省威宁县威宁黄牛繁育基地贵州省第七批人才基地项目(黔人领发[2020]1号) （黔人领发[2020]1号）
