基础医学与临床2025，Vol.45Issue(12)：1588-1592,5.DOI:10.16352/j.issn.1001-6325.2025.12.1588
血清SDF-1和MIP-1α在预测胆总管结石患者ERCP取石术后胆道感染中的临床价值
Clinical value of serum SDF-1 and MIP-1α in predicting biliary tract infection after ERCP stone removal in patients with common bile duct stones
摘要
Abstract
Objective To explore the clinical value of serum stromal cell-derived factor-1(SDF-1)and macro-phage inflammatory protein-1α(MIP-1α)in predicting biliary tract infection after endoscopic retrograde cholangiopancreatography(ERCP)stone removal in patients with common bile duct stones.Methods From January 2022 to January 2024,100 patients with common bile duct stones who underwent ERCP stone removal surgery in Pingdingshan First People's Hospital were collected.They were grouped into an infection group(12 cases)and a non-infection group(88 cases)based on whether biliary tract infection occurred after surgery.The general information of patients in the two groups was compared.ELISA method was used to measure the levels of serum SDF-1 and MIP-1α.Spearman method was applied to analyze the correlation between the severity of infec-tion and serum level of SDF-1 and MIP-1α.ROC curve was applied to analyze the value of serum SDF-1 and MIP-1α to predict biliary tract infection after ERCP stone removal in patients with common bile duct stones.Results A total of 36 strains of pathogenic bacteria were detected in the biliary drainage fluid samples of the infection group,among which Gram-negative bacteria accounted for 55.56%and Gram-positive bacteria accounted for 44.44%.The infection group showed significantly higher serum levels of SDF-1 and MIP-1α(P＜0.05).As the infection wors-ened,SDF-1 and MIP-1α levels progressively increased(P＜0.05).The severity of biliary tract infection was sig-nificantly positively correlated with both serum SDF-1 and MIP-1α levels(P＜0.05).For predicting biliary tract in-fection,SDF-1 and MIP-1α exhibited AUC values of 0.761 and 0.825,sensitivities of 63.33%and 66.67%,and specificities of 83.33%and 83.33%,respectively.When combined,the predictive AUC reached 0.977,with a sensitivity of 83.33%and a specificity of 98.33%.Conclusions Serum level of SDF-1 and MIP-1α are significant-ly elevated in patients with common bile duct stones and biliary tract infections after ERCP stone removal surgery,showing a positive correlation with the severity of the infection.The combination of these two biomarkers demon-strates excellent predictive efficacy for postoperative infection.关键词
基质细胞衍生因子-1/巨噬细胞炎性蛋白-1α/胆总管结石/内镜逆行胰胆管造影取石术/胆道感染Key words
stromal cell-derived factor-1/macrophage inflammatory protein-1α/common bile duct stones/endoscopic retrograde cholangiopancreatography stone removal/biliary tract infection分类
医药卫生引用本文复制引用
刘艳杰,王昭辉,白小彬..血清SDF-1和MIP-1α在预测胆总管结石患者ERCP取石术后胆道感染中的临床价值[J].基础医学与临床,2025,45(12):1588-1592,5.基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20200909) （LHGJ20200909）
