检验医学与临床2025，Vol.22Issue(23)：3169-3173,3180,6.DOI:10.3969/j.issn.1672-9455.2025.23.001
原发性肝癌患者介入治疗后血清GPC3、miR-424水平与复发的关系
Correlation between serum GPC3 and miR-424 levels and recurrence after intervention therapy in patients with primary liver cancer
摘要
Abstract
Objective To investigate the relationship between serum glypican-3(GPC3)and miR-424 lev-els and recurrence in patients with primary hepatocellular carcinoma(PHC)after interventional therapy.Methods A total of 130 patients with PHC who underwent interventional therapy in Baoji Gaoxin Hospital of Shaanxi Province from June 2020 to June 2023 were selected as the research objects.The patients were fol-lowed up for 6 months and divided into recurrence group and non-recurrence group according to the recurrence during the follow-up period.Multivariate Logistic regression was used to analyze the influencing factors of PHC recurrence after interventional therapy.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum GPC3,miR-424 alone and combined detection for the recurrence of PHC patients after interventional therapy.Pearson correlation analysis was used to analyze the correlation between serum GPC3 level and miR-424 level in PHC patients.Results There were 61 cases in the recurrence group and 64 cases in the non-recurrence group,and 5 cases were lost to follow-up during the study.The proportion of tumor maximum diameter≥5 cm,lymph node metastasis,microvascular invasion,and serum GPC3 level in the recurrence group were higher than those in the non-recurrence group,and the level of miR-424 was lower than that in the non-recurrence group,and the differences were statistically significant(P<0.05).Multivari-ate Logistic regression analysis showed that maximum tumor diameter≥5 cm,lymph node metastasis,micro-vascular invasion,increased GPC3 level were independent risk factors for recurrence of PHC after interven-tional therapy(P<0.05),and the increased miR-424 level was independent protective factor for recurrence of PHC after interventional therapy(P<0.05).The results of ROC curve analysis showed that the AUC of ser-um GPC3,miR-424 alone and their combination in predicting recurrence of PHC patients after interventional therapy were 0.792,0.789 and 0.896 respectively.The AUC of serum GPC3,miR-424 combined in predicting recurrence of PHC patients after interventional therapy was greater than that of serum GPC3,miR-424 alone(Z=2.563,2.930,P<0.05).Pearson correlation analysis showed that the level of serum GPC3 was negative-ly correlated with the level of miR-424 in PHC patients(r=-0.76,P=0.021).Conclusion Serum GPC3 and miR-424 are abnormally expressed in patients with recurrent PHC,and they are influencing factors for the recurrence of PHC after interventional therapy,which can be used as predictors of recurrence.关键词
原发性肝癌/磷脂酰肌醇蛋白聚糖-3/miR-424/复发/相关性/介入治疗Key words
primary liver cancer/glypican-3/miR-424/relapse/relevance/intervention therapy分类
医药卫生引用本文复制引用
杨帆,赵晓智,袁玥..原发性肝癌患者介入治疗后血清GPC3、miR-424水平与复发的关系[J].检验医学与临床,2025,22(23):3169-3173,3180,6.基金项目
陕西省重点研发计划项目(2020SF-043). （2020SF-043）
