检验医学与临床2025，Vol.22Issue(23)：3181-3185,3191,6.DOI:10.3969/j.issn.1672-9455.2025.23.003
胃肠充盈超声造影联合血清JAM2、DDIT4对早期胃癌患者淋巴结转移的诊断价值
Diagnostic value of contrast-enhanced ultrasonography combined with serum JAM2 and DDIT4 levels for lymph node metastasis in patients with early gastric cancer
摘要
Abstract
Objective To investigate the diagnostic value of gastrointestinal filling contrast-enhanced ultra-sound(GFUS)combined with serum junctional adhesion molecule 2(JAM2)and DNA damage inducible transcript 4(DDIT4)levels for lymph node metastasis(LNM)in patients with early gastric cancer(EGC).Methods A total of 51 EGC patients diagnosed in the hospital from June 2023 to June 2024 were selected as the study group,and they were divided into LNM group(22 cases)and non-LNM group(29 cases)according to whether LNM occurred.Fifty-three healthy volunteers who underwent physical examination in the hospital during the same period were selected as the control group.The serum levels of JAM2 and DDIT4 were detec-ted by enzyme-linked immunosorbent assay.The baseline data of all patients were collected.Pearson correla-tion analysis was used to analyze the correlation between serum JAM2,DDIT4 levels and GFUS indicators[peak intensity(PKI),rise time(RT)]in EGC patients.The receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of GFUS index combined with serum JAM2 and DDIT4 levels for LNM in EGC patients.Results The serum levels of JAM2 and DDIT4 in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The serum levels of JAM2,DDIT4 and PKI in the LNM group were higher than those in the non-LNM group,and the RT was shorter than that in the non-LNM group,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that serum JAM2 level in EGC patients was positively correlated with PKI(P<0.05)and negatively correlated with RT(P<0.05).DDIT4 level was positively correlated with PKI(P<0.05)and negatively correlated with RT(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum JAM2 and DDIT4 levels and PKI,RT in the diagnosis of LNM in EGC patients were 0.868,0.835,0.795 and 0.850 respectively.The AUC of combined diagnosis of the four indicators was 0.984,which was greater than the AUC of each indicator alone(Z=2.313,2.759,2.962,2.611,P<0.05).Conclusion Se-rum JAM2 and DDIT4 levels are increased in EGC patients,PKI,RT combined with serum JAM2 and DDIT4 levels have certain diagnostic value for LNM in EGC patients,and timely detection of PKI,RT index,serum JAM2 and DDIT4 levels is helpful to guide clinical practice.关键词
胃肠充盈超声造影/连接黏附分子2/DNA损伤诱导转录本4/早期胃癌/淋巴结转移/诊断Key words
gastrointestinal filling contrast-enhanced ultrasound/junctional adhesion molecule 2/DNA damage-inducing transcript 4/early gastric cancer/lymph node metastasis/diagnosis分类
医药卫生引用本文复制引用
袁静,王芬,郝永欣,霍英杰..胃肠充盈超声造影联合血清JAM2、DDIT4对早期胃癌患者淋巴结转移的诊断价值[J].检验医学与临床,2025,22(23):3181-3185,3191,6.基金项目
河北省廊坊市科学技术研究与发展计划项目(2022013121). （2022013121）
