检验医学与临床2025，Vol.22Issue(23)：3186-3191,6.DOI:10.3969/j.issn.1672-9455.2025.23.004
吸入用布地奈德联合茶碱类药物治疗急性发作期支气管哮喘患儿的疗效及对免疫气道功能的影响
Efficacy of inhaled budesonide combined with theophylline in the treatment of children with bronchial asthma at acute exacerbation and effect of immune airway function
摘要
Abstract
Objective To investigate the efficacy of inhaled budesonide combined with theophylline drugs in the treatment of children with bronchial asthma at acute exacerbation,and to analyze its effect on immune response and airway function in children.Methods A total of 84 children with bronchial asthma at acute exac-erbation admitted to Xuzhou Cancer Hospital from March 2021 to March 2022 were selected as the research objects.They were randomly divided into study group and control group by random number table method,with 42 cases in each group.Both groups were treated with inhaled budesonide,and the study group was trea-ted with aminophylline or doxofylline.The clinical efficacy,symptom improvement time,adverse reactions,Th1/Th2 ratio,nitric oxide(FeNO),alveolar nitric oxide(CaNO),nerve growth factor(NGF),and matrix metalloproteinase inhibitor 1(TIMP-1)levels before and after treatment were compared between the two groups.Results The total effective rate of the study group was 97.62%,which was higher than 85.71%of the control group,and the difference was statistically significant(P<0.05).Compared with the control group,the disappearance time of cough,wheezing and pulmonary rales in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in Th1/Th2 ratio,FeNO,CaNO,NGF and TIMP-1 levels between the two groups(P>0.05).After treatment,the Th1/Th2 ratio of the two groups was higher than that before treat-ment,and the levels of FeNO,CaNO,NGF and TIMP-1 were lower than those before treatment,and the Th1/Th2 ratio of the study group was higher than that of the control group,and the levels of FeNO,CaNO,NGF and TIMP-1 were lower than those of the control group,and the difference was statistically significant(P<0.05).The differences of Th1/Th2 ratio and CaNO,NGF and TIMP-1,and absolute value of FeNO difference before and after treatment in the study group were greater than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reac-tions between the study group and the control group(P>0.05).Conclusion The efficacy of budesonide com-bined with doxofylline or aminophylline in the treatment of bronchial asthma is better than that of budesonide suspension alone,which can accelerate the recovery of children,significantly improve the immune status and airway function of children.关键词
布地奈德/多索茶碱/氨茶碱/支气管哮喘/临床疗效/Th1/Th2比值/呼出气一氧化氮/肺泡气一氧化氮Key words
budesonide/doxofylline/aminophylline/bronchial asthma/clinical efficacy/Th1/Th2 ratio/exhaled nitric oxide/nitric oxide in alveolar air分类
医药卫生引用本文复制引用
顾静,武怡,张守康..吸入用布地奈德联合茶碱类药物治疗急性发作期支气管哮喘患儿的疗效及对免疫气道功能的影响[J].检验医学与临床,2025,22(23):3186-3191,6.基金项目
国家自然科学基金项目(81971179) （81971179）
江苏省徐州市妇幼卫生健康科研项目(KC22196). （KC22196）
