检验医学与临床2025，Vol.22Issue(23)：3192-3197,6.DOI:10.3969/j.issn.1672-9455.2025.23.005
基于少阳主枢理论探讨针灸治疗肝郁气滞型失眠患者的疗效及对GABA、CORT水平的影响
Based on Shaoyang principal axis theory,the efficacy of acupuncture and moxibustion in the treatment of insomnia patients with liver depression and qi stagnation and its effect on GABA and CORT levels were explored
摘要
Abstract
Objective To explore the therapeutic effect of acupuncture and moxibustion therapy based on Shaoyang principal axis theory on insomnia patients with liver depression and qi stagnation,and its effect on serum γ-aminobutyric acid(GABA)and cortisol(CORT)levels.Methods From January 2022 to December 2023,98 patients with insomnia of liver depression and qi stagnation in Daxing District Hospital of Integrated Traditional Chinese and Western Medicine were selected as the research objects.They were divided into con-trol group(49 cases)and study group(49 cases)by random number table method.On the basis of the control group,the study group was treated with acupuncture and moxibustion based on the guidance of Shaoyang principal axis theory.The TCM syndrome score,sleep quality,Hamilton anxiety scale(HAMA)score,Hamil-ton depression scale(HAMD)score,clinical efficacy,serum GABA and CORT levels before and after treat-ment,and the incidence of adverse reactions during treatment were compared between the two groups.Results After treatment,the main symptom score,secondary symptom score,total score,sleep quality,sleep latency,sleep time,sleep efficiency,sleep disorder,daytime dysfunction score,HAMA score and HAMD score of the two groups were lower than those before treatment,and those of the study group were lower than those of the control group,and the differences were statistically significant(P<0.05).The total effective rate of the study group was 95.92%(47/49),which was higher than 81.63%(40/49)of the control group,and the difference was statistically significant(P<0.05).After treatment,the GABA levels of the two groups were higher than those before treatment,and the CORT levels were lower than those before treatment,and the GA-BA level of the study group was higher than that of the control group,and the CORT level was lower than that of the control group,the differences were statistically significant(P<0.05).During the treatment,there were 2 cases of drowsiness,1 case of dizziness,and 1 case of fatigue in the control group,and 1 case of drowsi-ness and 1 case of fatigue in the study group.There was no significant difference in the incidence of adverse re-actions between the two groups(χ2=0.178,P=0.673).Conclusion The application of acupuncture and moxibustion based on Shaoyang main axis theory in the treatment of insomnia patients with liver depression and qi stagnation has a significant clinical effect,which can effectively relieve the clinical symptoms of pa-tients,improve the sleep quality of patients,anxiety and depression,increase the serum GABA level,and re-duce the serum CORT level,with high safety.关键词
失眠/肝郁气滞型/针灸/少阳主枢理论/γ-氨基丁酸/皮质醇Key words
insomnia/liver depression and qi stagnation/acupuncture and moxibustion/Shaoyang dominant pivot theory/γ-aminobutyric acid/cortisol分类
医药卫生引用本文复制引用
陈悦,孙美杰,冯乐伟..基于少阳主枢理论探讨针灸治疗肝郁气滞型失眠患者的疗效及对GABA、CORT水平的影响[J].检验医学与临床,2025,22(23):3192-3197,6.基金项目
北京市中医管理局项目(20190213). （20190213）
