检验医学与临床2025，Vol.22Issue(23)：3198-3202,5.DOI:10.3969/j.issn.1672-9455.2025.23.006
血清Gas6、NETs对创伤性骨折患者术后深静脉血栓形成的诊断价值
Predictive value of serum Gas6 and NETs for postoperative deep vein thrombosis in patients with traumatic fractures
摘要
Abstract
Objective To investigate the diagnostic value of serum growth arrest-specific protein 6(Gas6)and neutrophil extracellular traps(NETs)for postoperative deep vein thrombosis(DVT)in patients with traumatic fracture.Methods A total of 208 patients with traumatic fracture admitted to Daxing District Peo-ple's Hospital of Beijing from January 2023 to March 2024 were selected as the research objects.The patients were divided into DVT group(83 cases)and non-DVT group(125 cases)according to whether DVT occurred after operation.Enzyme-linked immunosorbent assay(ELISA)was used to detect the serum levels of Gas6 and NETs.The Caprini score was used to evaluate the risk of DVT in patients with traumatic fracture.Pear-son correlation analysis was used to analyze the correlation between serum Gas6,NETs and Caprini score in patients with traumatic fracture.Multivariate Logistic regression was used to analyze the risk factors of post-operative DVT in patients with traumatic fracture.The receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of serum Gas6,NETs alone and combined detection for postoperative DVT in patients with traumatic fracture.Results The PT and APTT in the DVT group were longer than those in the non-DVT group,the FIB and serum Gas6,NETs levels,as well as Caprini score were higher than that in the non-DVT group,and the differences were statistically significant(P<0.05).Pearson correlation alaysis results showed that the serum levels of Gas6 and NETs in patients with traumatic fracture were posi-tively correlated with Caprini score(r=0.378,0.460,P<0.05).Multivariate Logistic regression analysis showed that prolonged PT and APTT,increased FIB level,increased Caprini score,and increased serum Gas6 and NETs levels were risk factors for postoperative DVT in patients with traumatic fracture(P<0.05).The results of ROC curve analysis showed that the area under the curve(AUC)of serum Gas6,NETs and com-bined detection in the diagnosis of postoperative DVT in patients with traumatic fracture were 0.757,0.796 and 0.863 respectively.The AUC of combined detection of serum Gas6 and NETs was greater than that of single detection(Z=3.546,3.088,P<0.05).Conclusion The levels of serum Gas6 and NETs in patients with postoperative DVT of traumatic fracture are increased,which are risk factors for postoperative DVT in patients with traumatic fracture.The combined detection of the two can be used as a potential indicator for the diagnosis of postoperative DVT in patients with traumatic fracture.关键词
创伤性骨折/深静脉血栓形成/生长停滞特异性蛋白6/中性粒细胞胞外陷阱/诊断价值Key words
traumatic fractures/deep vein thrombosis/growth arrest-specific protein 6/neutrophil extracellular traps/diagnostic value分类
医药卫生引用本文复制引用
王帅,王卫粮,包雪艳,周牮,刘凯..血清Gas6、NETs对创伤性骨折患者术后深静脉血栓形成的诊断价值[J].检验医学与临床,2025,22(23):3198-3202,5.基金项目
北京市卫生健康科技项目(BHTPP2022072). （BHTPP2022072）
