检验医学与临床2025，Vol.22Issue(23)：3203-3207,3213,6.DOI:10.3969/j.issn.1672-9455.2025.23.007
肌骨超声和血清IL-6、DKK-1与类风湿关节炎患者病情活动度的相关性及对患者治疗反应性的影响
Correlation of musculoskeletal ultrasound,serum IL-6 and DKK-1 with disease activity and treatment response in patients with rheumatoid arthritis
摘要
Abstract
Objective To explore the correlation between musculoskeletal ultrasound,serum interleukin(IL)-6,Dickkopf-1(DKK-1)and disease activity in patients with rheumatoid arthritis(RA)and their effects on treatment response.Methods A total of 96 RA patients admitted to the hospital from January 2021 to Jan-uary 2023 were selected as the study group.In addition,96 healthy people who underwent physical examina-tion in the hospital during the same period were selected as the control group.The musculoskeletal ultrasound score,serum IL-6 and DKK-1 levels were compared between the two groups.According to disease activity score of 28 joints(DSA 28),the disease severity of the study group was divided into mild,moderate and se-vere.The musculoskeletal ultrasound score,serum IL-6 and DKK-1 levels of patients with different disease ac-tivity in the study group were compared.According to DSA 28 score,the study group was divided into re-sponse group and non-response group.Spearman correlation analysis was used to analyze the correlation be-tween musculoskeletal ultrasound score,serum IL-6,DKK-1 levels and RA disease activity.The receiver oper-ating characteristic(ROC)curve was used to analyze the value of musculoskeletal ultrasound score,serum IL-6,DKK-1 alone and combined detection in predicting non-response in RA patients.Results The musculoskel-etal ultrasound score,serum IL-6 and DKK-1 levels of the study group were higher than those of the control group,and the differences were statistically significant(P<0.05).In the study group,31 cases were mild,37 cases were moderate,and 28 cases were severe.The musculoskeletal ultrasound score,serum IL-6 and DKK-1 levels in severe patients were higher than those in moderate and mild patients,and the musculoskeletal ultra-sound score,serum IL-6 and DKK-1 levels in moderate patients were higher than those in mild patients,and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that musculo-skeletal ultrasound score,serum IL-6 and DKK-1 levels were positively correlated with RA disease activity in the study group(r=0.572,0.568,0.578,P<0.05).There were 26 cases in the non-response group and 70 cases in the response group.The disease activity,musculoskeletal ultrasound score,serum IL-6 and DKK-1 levels in the non-response group were higher than those in the response group,and the differences were statis-tically significant(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of musculo-skeletal ultrasound score,serum IL-6 and DKK-1 for predicting non-response in RA patients was 0.813,0.764 and 0.751,respectively.The AUC of the combination of the three for predicting non-response in RA patients was 0.914.The AUC of combined prediction was greater than that of each index alone(Z=0.193,2.309,2.355,P<0.05).Conclusion Musculoskeletal ultrasound score,serum IL-6 and DKK-1 levels are positively correlated with disease activity in RA patients.Combined prediction can provide reliable clinical evidence for e-valuating treatment response.关键词
类风湿关节炎/肌骨超声/白细胞介素-6/Dickkopf-1/病情活动度/治疗反应性Key words
rheumatoid arthritis/musculoskeletal ultrasound/interleukin-6/Dickkopf-1/Disease activity/treatment response分类
医药卫生引用本文复制引用
陈茜,杨涌,杨璐..肌骨超声和血清IL-6、DKK-1与类风湿关节炎患者病情活动度的相关性及对患者治疗反应性的影响[J].检验医学与临床,2025,22(23):3203-3207,3213,6.基金项目
2021年四川省医学(青年创新)科研课题(S21215). （青年创新）
