检验医学与临床2025，Vol.22Issue(23)：3208-3213,6.DOI:10.3969/j.issn.1672-9455.2025.23.008
清瘟败毒饮联合常规西药治疗脓毒症患者的临床疗效
Clinical efficacy of Qingwen Baidu decoction combined with conventional western medicine in the treatment of patients with sepsis
摘要
Abstract
Objective To explore the clinical efficacy of Qingwen Baidu decoction combined with conven-tional western medicine in the treatment of patients with sepsis.Methods A total of 66 patients with sepsis admitted to the hospital from January 2024 to September 2024 were selected as the research objects,and they were divided into control group and observation group by random number table method,with 33 cases in each group.The control group was treated with conventional Western medicine,and the observation group was treated with Qingwen Baidu decoction on the basis of the control group.The clinical efficacy,TCM syndrome score,Klotho and nuclear factor-κB(NF-κB)protein levels,coagulation function related indicators,inflamma-tory factors and adverse reactions were compared between the two groups.Results The effective rate of the observation group was 93.94%,which was higher than 72.73%of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of delirium,severe fever,dry mouth,irritabili-ty,total score,and the levels of NF-κB protein,D-dimer,fibrinogen,procalcitonin,C-reactive protein,tumor necrosis factor-α,and interleukin-6 in the two groups were lower than those before treatment,and the pro-thrombin time(PT)and activated partial thrombin time(APTT)were shorter than those before treatment,and the Klotho protein level and platelet count(PLT)were higher than those before treatment,and the scores of delirium,fever,dry mouth,total score,NF-κB protein level,D-dimer,fibrinogen,procalcitonin,C-reactive protein,tumor necrosis factor-α and interleukin-6 in the observation group were lower than those in the con-trol group,PT and APTT in the experimental group were shorter than those in the control group,and Klotho protein level and PLT in the experimental group were higher than those in the control group,and the differ-ences were all statistically significant(P<0.05).There was no significant difference in the incidence of ad-verse reactions between the two groups(P>0.05).Conclusion Qingwen Baidu decoction has a significant effect on the treatment of patients with sepsis,and it can improve the coagulation function of patients,reduce the level of inflammatory factors,with high safety,and has good clinical application value.关键词
脓毒症/清瘟败毒饮/Klotho/核转录因子-κB信号通路/临床疗效/炎症因子Key words
sepsis/Qingwen Baidu decoction/Klotho/nuclear factor-κB signaling pathway/clinical efficacy/inflammatory factor分类
医药卫生引用本文复制引用
白强,王惠,罗柔..清瘟败毒饮联合常规西药治疗脓毒症患者的临床疗效[J].检验医学与临床,2025,22(23):3208-3213,6.基金项目
湖南省中医药科研计划项目(C2024018). （C2024018）
