检验医学与临床2025，Vol.22Issue(23)：3214-3219,6.DOI:10.3969/j.issn.1672-9455.2025.23.009
颅内压监测联合脑组织氧分压监测在颅脑损伤开颅手术后的评估效果及对血清NSE、S100B水平的影响
Analysis of the evaluation effect of serum NSE and S100B on intracranial pressure monitoring combined with brain tissue oxygen partial pressure monitoring after craniotomy for craniocerebral injury
摘要
Abstract
Objective To investigate the effect of intracranial pressure(ICP)monitoring combined with brain tissue oxygen partial pressure(PbtO2)monitoring on the levels of serum S100 calcium binding protein B(S100B)and neuron specific enolase(NSE)in patients with craniocerebral injury after craniotomy.Methods A total of 93 patients with traumatic brain injury admitted to the hospital from January 1,2024 to December 30,2024 were selected as the research objects.According to the different placement methods,they were divided into the control group(ICP probe placement via Kocher point,31 cases)and the puncture group(ICP probe placement via paine point,31 cases),combined group(ICP probe implantation via paine point com-bined with PbtO2 monitoring,31 cases).The number of punctures,postoperative complications,activities of daily living(ADL)scores at 30 days,Glasgow outcome scale(GOS)scores at 3 months,total hospitalization costs,serum S100B and NSE levels were compared among the three groups.Results There were significant differences in the number of puncturing,operation time,ADL score at 30 d,and GOS score at 3 months among the 3 groups(P<0.05).The number of puncturing in the combined group and the puncture group was less than that in the control group,and the operation time in the puncture group was shorter than that in the con-trol group and the combined group,and the ADL score at 30 d and GOS score at 3 months in the combined group were higher than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of bleeding at the puncture site,intracranial infec-tion,death,hospitalization expenses,S100B,NSE,and ICP on admission and 7 d after admission,mean cerebral perfusion pressure,and times of PbtO2<20 mmHg among the three groups(P>0.05).On the 7th day after admission,there were statistically significant differences in S100B and NSE levels among the three groups(P<0.05).The levels of S100B and NSE in the combined group were lower than those in the control group,and the level of NSE was lower than that in the puncture group,and the differences were statistically signifi-cant(P<0.05).Conclusion In craniotomy for craniocerebral injury,the use of intracranial pressure probe through paine point for ICP monitoring can shorten the operation time and reduce the number of punctures.Combined with PbtO2 monitoring,it has a better effect on improving the prognosis of patients.S100B and ser-um NSE can be used as auxiliary indicators for evaluating the condition and judging the prognosis of cranioce-rebral injury,and have certain reference value.关键词
颅脑损伤/颅内压/脑组织氧分压/S100钙结合蛋白B/神经元特异性烯醇化酶Key words
craniocerebral injury/intracranial pressure/brain tissue oxygen partial pressure/S100 calcium binding protein B/neuron-specific enolase分类
医药卫生引用本文复制引用
张彪,刘备,杨彪,刘家骥,覃川..颅内压监测联合脑组织氧分压监测在颅脑损伤开颅手术后的评估效果及对血清NSE、S100B水平的影响[J].检验医学与临床,2025,22(23):3214-3219,6.基金项目
重庆市卫生健康委员会医学科研项目(2024WSJK100) （2024WSJK100）
重庆市大足区科技发展项目(DZKJ2023JSYJ-KWXM1008). （DZKJ2023JSYJ-KWXM1008）
