检验医学与临床2025，Vol.22Issue(23)：3220-3225,3232,7.DOI:10.3969/j.issn.1672-9455.2025.23.010
血清25(OH)D、β2-MG、GDF-15与妊娠期贫血患者贫血程度的相关性及对妊娠结局的预测价值
Correlation between serum 25(OH)D,β2-MG,GDF-15 and the degree of anemia in patients with anemia during pregnancy and the predictive value for pregnancy outcome
摘要
Abstract
Objective To investigate the correlation between serum levels of 25-hydroxyvitamin D[25(OH)D],β2-microglobulin(β2-MG)and growth differentiation factor 15(GDF-15)and the degree of anemia during pregnancy and their predictive value for pregnancy outcome.Methods A total of 112 patients with ane-mia during pregnancy diagnosed in the hospital from January 2022 to November 2023 were selected as the ob-servation group,and 80 healthy pregnant women who underwent physical examination in the hospital during the same period were selected as the control group.Whether the patients took folic acid,whether they had re-productive tract infection during pregnancy,and the levels of Hb,mean corpuscular volume(MCV)and mean corpuscular hemoglobin concentration(MCHC)were collected.The serum levels of 25(OH)D,β2-MG and GDF-15 in all subjects were detected by enzyme-linked immunosorbent assay.The pregnancy outcome of pa-tients with anemia during pregnancy was recorded,and the patients were divided into poor group and good group.Pearson and Spearman correlation were used to analyze the correlation between serum 25(OH)D,β2-MG,GDF-15 levels and Hb levels,MCV,MCHC and degree of anemia in patients with anemia during pregnan-cy.Multivariate Logistic regression was used to analyze the influencing factors of poor pregnancy outcomes in patients with anemia during pregnancy.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum 25(OH)D,β2-MG,GDF-15 alone and combined detection for poor pregnancy out-comes in patients with anemia during pregnancy.Results The levels of serum 25(OH)D and GDF-15 in the observation group were lower than those in the control group,and the level of β2-MG was higher than that in the control group,and the differences were statistically significant(P<0.05).The levels of serum 25(OH)D,GDF-15,Hb,MCV and MCHC in moderate anemia group and severe anemia group were lower than those in mild anemia group,the level of β2-MG in moderate anemia group and severe anemia group was higher than that in mild anemia group,and the levels of serum 25(OH)D,GDF-15,Hb,MCV and MCHC in severe anemia group were lower than those in moderate anemia group,the level of β2-MG in the anemia group was higher than that in the moderate anemia group,and the differences were statistically significant(P<0.05).The ser-um levels of 25(OH)D and GDF-15 were positively correlated with Hb levels,MCV,MCHC and negatively correlated with the degree of anemia during pregnancy(P<0.05).The level of β2-MG was negatively correla-ted with Hb levels,MCV,MCHC positively correlated with the degree of anemia(P<0.05).There were 65 cases in the good group and 47 cases in the poor group.The levels of serum Hb,25(OH)D,GDF-15 and MCHC in the poor group were lower than those in the good group,and the level of serum β2-MG was higher than that in the good group,and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that the increase of Hb,25(OH)D,GDF-15 levels and MCHC were protective fac-tors for poor pregnancy outcomes in patients with anemia during pregnancy(P<0.05),and the increase of β2-MG level was a risk factor for poor pregnancy outcomes in patients with anemia during pregnancy(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum 25(OH)D,β2-MG,GDF-15 alone and in combination to predict pregnancy outcomes in patients with anemia during pregnancy were 0.833,0.796,0.769,0.893 respectively,the AUC of combined detection was higher than that of single detection(Z=1.968,3.221,3.284,P<0.05).Conclusion The combined detection of serum 25(OH)D,GDF-15 and β2-MG in patients with anemia during pregnancy has a certain value in predicting pregnancy outcome.关键词
妊娠期贫血/25-羟基维生素D/β-2-微球蛋白/生长分化因子15/妊娠结局Key words
anemia during pregnancy/25-hydroxyvitamin D/β-2-microglobulin/growth differentia-tion factor 15/pregnancy outcome分类
医药卫生引用本文复制引用
高阿妮,周娟,梁娜,李延..血清25(OH)D、β2-MG、GDF-15与妊娠期贫血患者贫血程度的相关性及对妊娠结局的预测价值[J].检验医学与临床,2025,22(23):3220-3225,3232,7.基金项目
中华国际科学交流基金会检验检测科技专项基金项目(Z2020LSXB001). （Z2020LSXB001）
