生物技术通报2025，Vol.41Issue(11)：22-27,6.DOI:10.13560/j.cnki.biotech.bull.1985.2025-0941
人造淀粉生物合成技术:进展、挑战与展望
Artificial Starch Biosynthesis Technology:Progress,Challenges,and Prospects
摘要
Abstract
Artificial starch biosynthesis refers to an innovative process that converts raw materials such as carbon dioxide and cellulose into starch through technologies including the coupling of chemical and biological catalysis,metabolic pathway reconstruction,etc.,independent of traditional plant photosynthesis.Currently,the synthesis of starch from carbon dioxide has achieved a groundbreaking breakthrough in developing a brand-new unnatural carbon sequestration pathway;the conversion of cellulose into starch has made progress in the utilization of agricultural waste;and the synthesis of starch using yeast cells has shown potential in customized production.However,all three technical pathways face common issues of high cost,low efficiency,and difficulty in scaling up.This article reviews the technical principles and achievements of carbon dioxide-based starch synthesis,the pathways and application exploration of cellulose-to-starch conversion,as well as the modification mechanisms and potential of yeast cell-based starch synthesis.It also discusses the advantages,limitations,and common challenges of different technical routes.In the future,it is necessary to rely on innovations in enzyme engineering and synthetic biology to overcome the bottlenecks of cost,efficiency,and scaling up,and promote the industrial application of artificial starch in fields such as food security guarantee and carbon neutrality realization.关键词
人造淀粉/生物合成/二氧化碳/纤维素/酵母Key words
artificial starch/biosynthesis/CO2/cellulose/yeast引用本文复制引用
徐欣欣,李彦君,张伟,黄火清,罗会颖,姚斌..人造淀粉生物合成技术:进展、挑战与展望[J].生物技术通报,2025,41(11):22-27,6.基金项目
国家重点研发计划项目(2022YFA0912300),中国农业科学院重大科技任务(CAAS-ZDRW202304) （2022YFA0912300）
