陕西医学杂志2025，Vol.54Issue(12)：1635-1640,1649,7.DOI:10.3969/j.issn.1000-7377.2025.12.008
内脏肥胖指数与非肥胖人群高尿酸血症相关性研究及其预测价值
Correlation between VAI and HUA,UA level in non-obese population and its predictive value
摘要
Abstract
Objective:To investigate the association between Visceral Adiposity Index(VAI)and the hyperuri-cemia(HUA)as well as serum uric acid(UA)level in non-obese individuals,and to evaluate its potential predictive value.Methods:A total of 1553 non-obese adults who underwent health examinations were included in this study.A secondary screening was conducted on individuals with elevated UA level,and they were grouped based on whether they had HUA.The associations between VAI and HUA,UA level were analyzed using R 4.2.0 and EmpowerRCH 4.2.Interaction analyses were performed stratified by gender,age,smoking status,alcohol consumption history,and pre-existing medical conditions.The predictive value of VAI for HUA was assessed using ROC curve.Results:Sub-group analysis showed that reducing VAI would bring more benefits to women,individuals aged 50 years or older,and people with HUA.When ln VAI was used as a continuous variable,after adjusting for 13 potential confounding factors,including age,gender,and smoking history,each one-unit increase in ln-transformed VAI was associated with a 5.13-fold increased likelihood of being diagnosed with HUA,along with an average increase of 21.30 units in UA level(all P<0.05).When ln VAI was treated as a categorical variable,individuals in the high VAI group exhibited a 9.37-fold higher prevalence of HUA compared to those in the low VAI group,with a corresponding increase of 65.33 units in UA level(all P<0.05).ROC curve analysis showed that VAI had a good predictive value for HUA(P<0.05).Conclusion:In non-obese population,VAI has a significant non-linear positive correlation with HUA prevalence and UA lev-el,and has a good predictive value for HUA,which can be used for the early identification of HUA in non-obese population.关键词
高尿酸血症/内脏肥胖指数/血尿酸/非肥胖人群/相关性/预测价值Key words
Hyperuricemia/Visceral Adiposity Index/Uric acid/Non-obese population/Correlation/Predictive value分类
医药卫生引用本文复制引用
吴梓敬,李纪新,邱林杰,任燕,李美洁,栗文婕,邹姹姹,张睿,张晋..内脏肥胖指数与非肥胖人群高尿酸血症相关性研究及其预测价值[J].陕西医学杂志,2025,54(12):1635-1640,1649,7.基金项目
国家重点研发计划子课题(2018YFC2000604) （2018YFC2000604）
北京中医药薪火传承"3+3"工程项目(2023-SZ-A51) （2023-SZ-A51）
中国中医科学院科技创新工程(CI2021A03005) （CI2021A03005）
中国中医科学院西苑医院具有知识产权的医疗机构制剂和中药新药的研发与转化专项课题(XYZY0301-16) （XYZY0301-16）
