实用肿瘤杂志2025，Vol.40Issue(6)：539-545,7.DOI:10.13267/j.cnki.syzlzz.2025.077
内镜黏膜下剥离术治疗结直肠癌的研究进展
Progress in research on endoscopic submucosal dissection for colorectal cancer
摘要
Abstract
Colorectal cancer(CRC)represents one of the most prevalent malignancies worldwide.Conventional therapeutic approaches are frequently associated with compromised organ function and reduced quality of life.Endoscopic submucosal dissection(ESD),a curative minimally invasive technique indicated for early-stage CRC,achieves en bloc resection of neoplastic lesions through precise submucosal dissection,thereby significantly diminishing local recurrence rates.Consequently,ESD has progressively supplanted radical surgery as a cornerstone therapeutic strategy.This review systematically synthesizes recent advancements in ESD for CRC management,encompassing the evolution of its indications and contraindications,clinical efficacy and complication profiles,therapeutic outcomes in ulcerative coli-tis-associated neoplasia,and the instrumental innovations(particularly robotic-assisted systems)propelling technical refinement.Collec-tively,ESD is reshaping the CRC treatment paradigm toward organ-preserving,minimally invasive,and curative interventions,wherein standardization and sustained technical progress remain pivotal for optimizing clinical outcomes.关键词
结直肠癌/内镜黏膜下剥离术/治疗效果/溃疡性结肠炎相关肿瘤性病变Key words
colorectal cancer/endoscopic submucosal dissection/therapeutic effect/ulcerative colitis-associated neoplasia引用本文复制引用
黄小玉,王君澍,苗格,王好甲,张渊慈,刘震雄,赵晓迪,王新..内镜黏膜下剥离术治疗结直肠癌的研究进展[J].实用肿瘤杂志,2025,40(6):539-545,7.基金项目
国家自然科学基金面上项目(82173256) （82173256）
陕西省重点研发计划(2024SF-GJHX-04) （2024SF-GJHX-04）
消化系肿瘤整合防治全国重点实验室课题(CBSKL2022ZZ55) （CBSKL2022ZZ55）
