实用中医内科杂志2025，Vol.39Issue(11)：17-20,4.DOI:10.13729/j.issn.1671-7813.Z24111406
基于肠道菌群探究中药多糖改善2型糖尿病研究进展
Research Progress of Traditional Chinese Medicine Polysaccharide Intervention in Type 2 Diabetes Mellitus based on the Exploration of Intestinal Flora
摘要
Abstract
In recent years,type 2 diabetes mellitus(T2DM)is posing a serious threat to human health with its high preva-lence due to the dramatic shifts in socio-environmental factors,human genetics,and lifestyle structural factors,and in-depth elucidation of the etiology of the disease and search for better preventive and curative strategies are the key bottlenecks in the cur-rent research on T2DM.As the prevalence of T2DM continues to rise,its research has been deepened,and it is believed that intes-tinal flora dysbiosis is one of the important risk factors for T2DM.Several studies have shown that traditional Chinese medicine polysaccharides can regulate the intestinal flora for the treatment of T2DM,and traditional Chinese medicine is an important part of the motherland's medicine,with a variety of components,multiple targets and multiple pathways,which has significant advanta-ges.However,the structure and distribution of intestinal flora in patients with T2DM are significantly different from those of nor-mal people,and the mechanism of traditional Chinese medicine polysaccharides in treating T2DM by regulating intestinal flora has not yet been clarified.In this paper,we focus on the alteration of the intestinal flora of T2DM by traditional Chinese medicine pol-ysaccharides by reviewing the research results of the intervention of traditional Chinese medicine polysaccharides on T2DM in or-der to provide a theoretical basis for the development of new medicines and clinical application of traditional Chinese medicine polysaccharides in the intervention of T2DM.关键词
中药多糖/肠道菌群/2型糖尿病/胰岛素抵抗/作用机制Key words
polysaccharides of Chinese medicine/intestinal flora/type 2 diabetes/insulin resistance/mechanism of action分类
医药卫生引用本文复制引用
肖其富,段学清,邓滢滢,刘一凡,田维毅..基于肠道菌群探究中药多糖改善2型糖尿病研究进展[J].实用中医内科杂志,2025,39(11):17-20,4.基金项目
国家自然科学基金项目(82060824) （82060824）
贵州省科学技术厅科技计划项目(黔科合平台人才-ZDSYs[2023]004) （黔科合平台人才-ZDSYs[2023]004）
