外科理论与实践2025，Vol.30Issue(5)：409-416,8.DOI:10.16139/j.1007-9610.2025.05.06
KIF15、EGFR与HER2在胆囊癌中的表达及临床意义
Expression and clinical significance of KIF15,EGFR,and HER2 in gallbladder cancer
摘要
Abstract
Objective To investigate the expression of kinesin family member 15(KIF15),epidermal growth factor receptor(EGFR),and human epidermal growth factor receptor 2(HER2)in gallbladder cancer(GBC)and their clinical and pathological significance.Methods Immunohistochemical staining was employed to detect the expression of KIF15,EGFR,and HER2 proteins in GBC tissue microarrays.The correlation between protein expression levels and various clinical and pathological characteristics of GBC patients was analyzed.Results The positive expression rates of KIF15,EGFR,and HER2 proteins in GBC tissues were 71.6%,62.2%,and 51.4%respectively,compared to 16.7%,0,and 0 in para-carcinoma tissues(all P=0.000).KIF15 expression was correlated with cancer differentiation grade(P=0.006),while EGFR expression was associated with lymph node metastasis(P=0.026)and the number of metastatic lymph nodes(P=0.012).HER2 expression was correlated with cancer differentiation grade(P=0.018),tumor size(P=0.005),and T stage(P=0.032).GBC patients with co-positive expression of KIF15 and HER2 had significantly lower overall survival compared to those with negative expression.Positive HER2 expression,lymph node metastasis,and the number of metastatic lymph nodes were identified as independent risk factors for overall survival in GBC patients.Conclusions Positive expression of KIF15,EGFR,and HER2 in GBC tissues are correlated with various clinical indicators and poorer prognosis.These proteins may serve as potential factors for predicting prognosis and evaluating therapeutic efficacy in GBC.关键词
胆囊癌/驱动蛋白家族成员15/表皮生长因子受体/人表皮生长因子受体2/临床病理特征/预后Key words
Gallbladder cancer(GBC)/Kinesin family member 15(KIF15)/Epidermal growth factor receptor(EGFR)/Human epidermal growth factor receptor 2(HER2)/Clinical and pathological characteristics/Prognosis分类
医药卫生引用本文复制引用
王军,王路兵,胡刚峰,章波,黄侠,黄磊..KIF15、EGFR与HER2在胆囊癌中的表达及临床意义[J].外科理论与实践,2025,30(5):409-416,8.基金项目
上海健康医学院附属崇明医院院级课题(CMYY2023-02) （CMYY2023-02）
上海健康医学院师资人才百人库产学研践习项目(2024) （2024）
上海健康医学院附属崇明医院第四届优秀青年医学人才培养计划(2023) （2023）
上海市崇明区"可持续发展科技创新行动计划"(CKY2023-21) （CKY2023-21）
