心理学报2025，Vol.57Issue(12)：2116-2130,15.DOI:10.3724/SP.J.1041.2025.2116
童年期虐待与青少年自伤行为:下丘脑-垂体-肾上腺轴多基因及抑郁的作用
Childhood abuse and adolescent non-suicidal self-injury:The effects of hypothalamic-pituitary-adrenal axis multilocus genetic variation and depression
摘要
Abstract
Exposure to childhood abuse increases the risk of non-suicidal self-injury among adolescents.However,the underlying mechanism remains unclear.Based on the theoretical perspective of gene × environment-endophenotype-behavioral phenotype,hypothalamic-pituitary-adrenal(HPA)axis genetic variation as an indicator of individual diathesis or susceptibility has been shown to interact with childhood trauma to affect adolescent non-suicidal self-injury.Additionally,depression as a potential endophenotype for non-suicidal self-injury can be considered a pathway through which childhood abuse and HPA axis genetic variation interactively affect adolescent non-suicidal self-injury.Accordingly,the present study sought to investigate the moderating role of multilocus genetic profile score(MGPS)of the HPA axis and the mediating role of depression in the association between childhood abuse and adolescent non-suicidal self-injury. The present study included two independent samples(the main sample included 407 adolescents,Mage=12.77,SD=0.74;another retest sample included 109 adolescents,Mage=12.54,SD=0.60).Scales including the Childhood Trauma Questionnaire-Short Form,Center for Epidemiological Studies-Depression Scale,and Non-suicidal Self-injury Scale derived from the Revised Diagnostic Interview for Borderlines were administered to adolescents.Their saliva samples were collected for DNA genotyping to obtain the polymorphisms of CRHR1 rs110402,FKBP5 rs1360780,rs4713902,NR3C1 rs41423247,and COMT rs4680.The HPA axis MGPS was calculated according to the number of at-risk or susceptible genotypes carried,with higher levels representing higher genetic risk or susceptibility. Results showed that childhood abuse was positively associated with adolescent non-suicidal self-injury.In addition,although childhood abuse and HPA axis MGPS had no direct interactive effect on adolescent non-suicidal self-injury,they indirectly interactively affect adolescent non-suicidal self-injury via depression.Specifically,compared with adolescents with low HPA axis MGPS,those with high HPA axis MGPS showed a stronger positive association between childhood abuse and depression,which increased the risks of non-suicidal self-injury.Similar results were obtained in the retest sample,with a positive relation between childhood abuse and depression only observed among adolescents with high HPA axis MGPS who have increased risks of non-suicidal self-injury.The re-parameterized regression model tests in both samples suggested that the pattern of interaction between childhood abuse and HPA axis MGPS supported the diathesis-stress model. Findings of the present study supported the theoretical perspective of gene × environment-endophenotype-behavioral phenotype,by suggesting that childhood abuse interacts with the HPA axis genetic variants to affect non-suicidal self-injury via depression among adolescents.These findings shed light on the underlying mechanism linking childhood abuse with adolescent non-suicidal self-injury.关键词
童年期虐待/自伤/抑郁/下丘脑-垂体-肾上腺轴/多基因累加得分Key words
childhood abuse/non-suicidal self-injury/depression/hypothalamic-pituitary-adrenal axis/multilocus genetic profile score分类
社会科学引用本文复制引用
伍越,吕薇..童年期虐待与青少年自伤行为:下丘脑-垂体-肾上腺轴多基因及抑郁的作用[J].心理学报,2025,57(12):2116-2130,15.基金项目
国家自然科学基金面上项目(32171066). （32171066）
