新医学2025，Vol.56Issue(11)：1109-1115,7.DOI:10.12464/j.issn.0253-9802.2025-0200
他莫昔芬治疗特发性少精症的疗效及耐受性研究
Efficacy and tolerance of tamoxifen in the treatment of idiopathic oligozoospermia
摘要
Abstract
Objective To evaluate the efficacy and tolerance of tamoxifen(TAM)in the treatment of idiopathic oligozoospermia.Methods Clinical data of 123 patients diagnosed with idiopathic oligozoospermia in Department of Sterility and Sexual Medicine of the Third Affiliated Hospital of Sun Yat-sen University from February 1,2021 to August 30,2023 were retrospectively analyzed.All patients with a sperm density of＜15×106/mL were treated with 10 mg TAM twice a day for 4 months or longer.The changes of semen(n=123)and serum hormones(n=71)were assessed in patients with idiopathic oligozoospermia treated with TAM.The efficacy of TAM for oligozoospermia was evaluated.Sperm parameters and hormones among different groups were compared by Friedman test,and two-group comparison was performed by Bonferroni's correction.Results After treating 3 and 4 months,the sperm density(Z=7.428,5.101;both P＜0.05)and the total number of sperm(Z=6.280,3.379;both P＜0.05)in patients with idiopathic oligozoospermia were increased compared with those before treatment.Compared with treating for 3 months,the total number of sperm was decreased after treating for 4 months(Z=-2.901,P=0.011).Compared with before treatment,the total sperm motility tended to increase after 3-and 4-month TAM treatment,but the differences were not statistically significant(Z=4.503,P=0.105).Compared with before treatment,the serum testosterone levels(Z=5.203,4.238;both P＜0.05)and the estradiol levels(Z=3.944,3.734;both P＜0.05)were increased after 3-and 4-months TAM treatment.Compared with before treatment,the improvement rate of sperm density was 62.6%(77/123)after 3 months TAM treatment and 49.6%(61/123)after 4 months TAM treatment.Conclusions TAM can enhance the sperm density and total number of sperm in patients with idiopathic oligozoospermia.However,special attention should be paid to the efficacy and tolerance of TAM treatment.关键词
他莫昔芬/特发性少精症/睾酮/雌二醇/耐受Key words
Tamoxifen/Idiopathic oligozoospermia/Testosterone/Estradiol/Tolerance引用本文复制引用
刘卓杰,张炎,张浩..他莫昔芬治疗特发性少精症的疗效及耐受性研究[J].新医学,2025,56(11):1109-1115,7.基金项目
国家重点研发计划(2022YFC2702703) （2022YFC2702703）
