新医学2025，Vol.56Issue(11)：1116-1122,7.DOI:10.12464/j.issn.0253-9802.2025-0203
声触诊弹性成像与肝脏纤维化评分评估肝硬化高风险食管静脉曲张的比较
Comparison of sound touch elastography and liver fibrosis scores in assessing high-risk esophageal varices in patients with liver cirrhosis
摘要
Abstract
Purpose To evaluate and compare the diagnostic efficiency of sound touch elastography(STE)and liver fibrosis scores(APRI,FIB-4)for high-risk esophageal varices(HREV)in patients with liver cirrhosis,providing evidence for clinical application of STE.Methods 148 patients diagnosed with liver cirrhosis in the Third Affiliated Hospital of Sun Yat-sen University between August 2018 and December 2021 were included.Clinical data and serological results were collected.Patients underwent electronic gastroscopy,abdominal ultrasound,and STE examinations for liver/spleen stiffness measurement.With gastroscopy as the gold standard,Logistic regression was performed to identify the independent risk factors for HREV,and construct the regression model.The area under the receiver operating characteristic(ROC)curve(AUC)was used to assess the diagnostic efficiency of each non-invasive model.Results Spleen stiffness and platelet count(PLT)were the independent risk factors of HREV.The regression model was established as Logit P=0.125×spleen stiffness(kPa)-0.018×PLT(×109/L)-2.262.The AUC for liver stiffness,spleen stiffness,the regression model,APRI,and FIB-4 was 0.67(0.59,0.75),0.83(0.76,0.88),0.86(0.79,0.91),0.69(0.61,0.76)and 0.75(0.68,0.82),respectively.Conclusion The regression model based on spleen stiffness and PLT shows high diagnostic value for HREV in patients with liver cirrhosis,which outperforms APRI and FIB-4.关键词
声触诊弹性成像/肝脏纤维化评分/食管静脉曲张/肝硬化/肝脏硬度/脾脏硬度Key words
Sound touch elastography/Liver fibrosis scores/Esophageal varices/Cirrhosis/Liver stiffness/Spleen stiffness引用本文复制引用
邝小红,吴曼丽..声触诊弹性成像与肝脏纤维化评分评估肝硬化高风险食管静脉曲张的比较[J].新医学,2025,56(11):1116-1122,7.基金项目
国家自然科学基金(82202191) （82202191）
