右江医学2025，Vol.53Issue(11)：974-981,8.DOI:10.3969/j.issn.1003-1383.2025.11.002
网络药理学对蒲公英萜醇治疗结直肠癌的多维度调控机制研究
Study on multi-dimensional regulatory mechanism of network pharmacology on dandelion terpenoids in the treatment of colorectal cancer
摘要
Abstract
Objective To identify the targets of taraxerol(TAX)in the treatment of colorectal cancer(CRC),so as to provide theoretical basis for new treatment strategies.Methods PharmMapper and SwissTarget Prediction were used to pre-dict the therapeutic targets of dandelion terpenoids,and standardization was performed by UniProt.The GSE83129 dataset was downloaded from the GEO database,and limma package was used to screen the differentially expressed genes(DEGs).The therapeutic target of TAX was intersected with the DEGs by Venny,and the target of TAX for the treatment of CRC was obtained.And the protein-protein interaction network(PPI network)was constructed through STRING and Cytoscape to screen the hub genes.The KEGG signaling pathways of hub genes were identified through GO/KEGG enrichment analysis,and the structure of the hub genes was obtained from PDB,and the molecular docking test with TAX was conducted by AutoDock Tools.Finally,the docking results were visualized through PyMOL.Results Through the PPI network,32 hub genes were identified,including HSP90AB1,HSP90AA1,and CDK2,etc.Signaling pathways such as PI3K-Akt,p53,nod-like receptors(NLRS),and interleukin-17(IL-17)might be involved in the pathogenesis of colorectal cancer(CRC).Conclusion TAX can target the HSP90AB1,HSP90AA1,CDK2 genes,as well as the PI3K-Akt signaling pathway,p53 signaling pathway,NOD-like receptor signaling pathway and IL-17 signaling pathway to treat colorectal cancer,which indi-cates that TAX can be used as a potential drugs for the treatment of CRC,laying a theoretical foundation for the subsequent verification of therapeutic effects.关键词
结直肠癌/蒲公英萜醇/网络药理学/枢纽基因/信号通路Key words
colorectal cancer(CRC)/taraxerol(TAX)/network pharmacology/hub genes/signaling pathways分类
医药卫生引用本文复制引用
龙鹏臣,刘通,王运成,苏弟..网络药理学对蒲公英萜醇治疗结直肠癌的多维度调控机制研究[J].右江医学,2025,53(11):974-981,8.基金项目
广西壮族自治区卫生健康委员会西药类自筹经费研究项目(Z-L20231805) （Z-L20231805）
