右江医学2025，Vol.53Issue(11)：1002-1009,8.DOI:10.3969/j.issn.1003-1383.2025.11.006
纳布啡联合罗哌卡因腹横肌平面阻滞对腹腔镜下全子宫切除术患者的影响
Effect of nalbuphine combined with ropivacaine for transverse abdominis plane block on patients undergoing laparoscopic total hysterectomy
摘要
Abstract
Objective To investigate the effects of nalbuphine combined with ropivacaine transversus abdominis plane block(TAPB)on stress response,inflammatory reactions,postoperative analgesia,and adverse reactions in patients under-going laparoscopic total hysterectomy.Methods A total of 60 patients who underwent laparoscopic total hysterectomy at the Affiliated Hospital of Youjiang Medical University for Nationalities between January 2022 and January 2023 were randomly divided into group A(ropivacaine TAPB,n=30)and group B(nalbuphine combined with ropivacaine TAPB,n=30).And then,intraoperative stress indicators(norepinephrine[NE]and cortisol[Cor]),inflammatory indicators(C-reactive pro-tein[CRP]),dosage of anesthetic drugs(propofol and remifentanil),postoperative visual analog scale(VAS)and sufen-tanil dosage at 2,6,12,and 24 hours after surgery,as well as the incidence of adverse reactions between two groups were compared.Results There were no statistically significant differences in baseline NE,Cor and CRP levels between the two groups(P>0.05).Compared with the group A,the group B showed a more significant decrease in intraoperative NE and Cor levels(P-values for inter group and time interaction were 0.006 and 0.016,respectively),while there was no statisti-cally significant difference in CRP levels between the groups(P=0.185).In the group B,propofol and remifentanil doses showed significant reduction(P<0.05).Postoperatively,VAS scores and sufentanil doses at all time points demonstrated significant decreases(P<0.05).There was no significant difference in the incidence of adverse reactions between groups(P>0.05).Conclusion Nalbuphine combined with ropivacaine TAPB in laparoscopic total hysterectomy can effectively alleviate patients'stress reactions,reduce the dosage of anesthetic drugs,enhance postoperative analgesic effects,without increasing the risk of adverse reactions.关键词
纳布啡/腹横肌平面阻滞/腹腔镜全子宫切除术/术后镇痛/应激反应Key words
nalbuphine/transversus abdominis plane block(TAPB)/laparoscopic total hysterectomy/postoperative analgesia/stress response分类
医药卫生引用本文复制引用
黎慧玲,VOEURN CHHING,王萧潇,覃英..纳布啡联合罗哌卡因腹横肌平面阻滞对腹腔镜下全子宫切除术患者的影响[J].右江医学,2025,53(11):1002-1009,8.基金项目
广西医疗卫生适宜技术开发与推广应用项目(S2022137) （S2022137）
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20190382) （Z20190382）
百色市科学研究与技术开发计划项目(百科20221411) （百科20221411）
右江民族医学院校级硕士研究生创新项目(YZCXJH2023007) （YZCXJH2023007）
