中国人兽共患病学报2025，Vol.41Issue(10)：1048-1054,7.DOI:10.3969/j.issn.1002-2694.2025.00.156
新疆某传染病医院非结核分枝杆菌肺病流行病学及临床特征分析
Epidemiologic and clinical characterization of nontuberculous mycobacterial lung disease in a certain infectious disease hospital in Xinjiang
摘要
Abstract
To understand the epidemiological and clinical features of patients with non-tuberculous mycobacteria(NTM)lung disease in a hospital for infectious diseases in Xinjiang,and to provide basis for prevention and control of NTM in Xinjiang.The strain distribution,epidemiological features and clinical features of 78 patients with NTM lung disease in the Sixth People′s Hospital of Xinji-ang Uygur Autonomous Region were analysed from June 2021 to June 2024,and a comparative analysis of the clinical features of 156 patients with pulmonary tuberculosis in this hospital during the same period was performed.Among 78 patients with NTM lung disease,the bacteria identified by molecular biology accounted for the top three cases:24 cases of Mycobacterium avium intracellulare complex,16 cases of Mycobacterium Kansaii and 11 cases of Mycobacterium Gordonae.There was no statistically significant difference in gender(χ2=0.009),age(χ2=2.670),smoking history(χ2=0.064),and BMI(χ2=0.896)between the NTM lung disease group and the pulmonary tuberculosis group(P>0.05).However,there were statistically significant differences in the combined bronchiectasis(χ2=19.068),immune-related indicators CD4(Z=-3.498)and CD3(Z=-3.187),and chest CT cavities on imaging(χ2=9.308)be-tween the two groups(P<0.05).There was no statistically significant difference in clinical symptoms such as cough(χ2=0.188)and expectoration(χ2=0.044)between the two groups(P>0.05).The common underlying diseases of NTM lung disease were diabetes mellitus(23.08%),hypertension(21.79%),bronchiectasis(20.51%)and others.The common clinical symptoms of NTM lung disease include cough,sputum,fatigue,poor appetite and others.The common manifestations of chest CT in NTM lung disease were Patchy cord shadows(62.82%),nodule(51.28%),pleural thickening(46.15%),calcification(41.03%)and others.Multivariate Logistic regression analysis showed that bronchiectasis(OR=8.019)is risk factor for NTM lung disease.The dominant strains of NTM in this study were My-cobacterium avium intracellulare complex,Mycobacterium kansasii and Mycobacterium Gordonae.NTM lung disease and pulmonarytuber-culosis have similar clinical manifestations and are difficult to distinguish,especially for patients with bronchiectasis,it is necessary to actively investigate NTM lung disease,provide basis for early diagnosis and treatment of NTM lung disease,and gradually form a system-atic and standardized NTM lung disease diagnosis and treatment system according to local conditions.关键词
非结核分枝杆菌肺病/菌种分布/流行病学/临床特征Key words
non-tuberculous mycobacterial lung disease/strain distribution/epidemiology/clinical features分类
医药卫生引用本文复制引用
庞茜,王泉,逄宇,马瑞瑛,杨婷,古丽比克·木拉提,阿尔泰..新疆某传染病医院非结核分枝杆菌肺病流行病学及临床特征分析[J].中国人兽共患病学报,2025,41(10):1048-1054,7.基金项目
新疆维吾尔自治区自然科学基金(No.2021D01A160) Natural Science Foundation of Xinjiang Uygur Autonomous Region(No.2021D01A160) （No.2021D01A160）
