中国输血杂志2025，Vol.38Issue(11)：1542-1547,6.DOI:10.13303/j.cjbt.issn.1004-549x.2025.11.010
血小板聚集率对脓毒症相关凝血功能障碍的诊断和预后价值
Diagnostic and prognostic value of platelet aggregation rate in sepsis-associated coagulation disorders
摘要
Abstract
Objective To analyze the diagnostic and prognostic value of platelet aggregation rate in sepsis-related coag-ulation disorders.Methods A total of 238 patients with sepsis were enrolled from Xinjiang Uygur Autonomous Region Peo-ple's Hospital between June 2021 to June 2024.Patients were divided into coagulation dysfunction group(n=142)and non-dysfunction group(n=96)based on the occurrence of sepsis-related coagulation dysfunction.The general data,platelet aggregation rate and coagulation-related indicators of the two groups were compared.The 28-day survival outcomes were e-valuated,and platelet aggregation rates were compared between survivors and non-survivor groups.Factors influencing the occurrence of sepsis-related coagulation dysfunction were analyzed.ROC curves were used to evaluate the predictive value of platelet aggregation rate for the prognosis of sepsis-related coagulation dysfunction.Results Compared to the non-dysfunc-tion group,APACHE Ⅱ score,procalcitonin(PCT),activated partial thromboplastin time(APTT),platelet aggregation rate,and SOFA score were higher in the dysfunction group,while fibrinogen(Fib)was lower in the dysfunction group(P<0.05).The values were:(18.30±2.00)points vs(10.76±1.42)points,(7.27±2.10)ng/mL vs(3.87±1.62)ng/mL,(46.78±3.22)s vs(40.43±0.90)s,(69.07±6.32)%vs(55.78±2.96)%,(7.91±2.21)points vs(4.72±1.76)points,(243.23±40.91)mg/dL vs(342.09±46.58)mg/dL,respectively.The APTT、PCT level,platelet aggregation rate,A-PACHE Ⅱ score and SOFA score were all risk factors for the development of sepsis-related coagulation dysfunction(OR>1,P<0.05).The platelet aggregation rate was higher in the non-survivor group compared to the survivor group(74.10±5.19 vs 66.05±4.87,P<0.05).The combination of platelet aggregation rate and PCT yielded the highest AUC for prediction,which was significantly greater than that of either single indicator(platelet aggregation rate:AUC=0.868;PCT:AUC=0.854,P<0.05).Conclusion Platelet aggregation rate is an independent risk factor for the development of sepsis-associ-ated coagulation dysfunction,and also an effective predictor for the prognosis of patients with sepsis coagulation dysfunction.关键词
脓毒症/相关凝血功能障碍/血小板聚集率/诊断/预后Key words
sepsis/sepsis-associated coagulation dysfunction/platelet aggregation rate/diagnosis/prognosis分类
医药卫生引用本文复制引用
王儒彬,马筱洁,李菲,陈伟..血小板聚集率对脓毒症相关凝血功能障碍的诊断和预后价值[J].中国输血杂志,2025,38(11):1542-1547,6.基金项目
新疆维吾尔自治区自然科学基金面上项目(2023D01C73) （2023D01C73）
新疆维吾尔自治区自然科学基金青年科学基金(2022D01C807) （2022D01C807）
新疆维吾尔自治区"天山英才"医药卫生高层次人才项目(TSYC202401B157) （TSYC202401B157）
新疆维吾尔自治区自然科学基金面上项目(2022D01C637) （2022D01C637）
新疆维吾尔自治区人民医院院内项目(20190409) （20190409）
新疆维吾尔自治区人民医院院内项目(20230239) （20230239）
