中国药房2025，Vol.36Issue(23)：2930-2934,5.DOI:10.6039/j.issn.1001-0408.2025.23.08
通心络胶囊对利伐沙班在大鼠体内药代动力学的影响
Effects of Tongxinluo capsules on pharmacokinetics of rivaroxaban in rats
摘要
Abstract
OBJECTIVE To investigate the impact of Tongxinluo capsules on the pharmacokinetics of rivaroxaban in rats.METHODS Rats were randomly divided into rivaroxaban alone group(2.70 mg/kg),low-dose Tongxinluo capsules combined with rivaroxaban group(Tongxinluo capsules 0.28 g/kg+rivaroxaban 2.70 mg/kg),and high-dose Tongxinluo capsules combined with rivaroxaban group(Tongxinluo capsules 0.84 g/kg+rivaroxaban 2.70 mg/kg),with five rats in each group.Following seven consecutive days of gavage with normal saline or the corresponding doses of Tongxinluo capsules,the rats were subjected to a final gavage administration of rivaroxaban.Blood samples were collected at 0 h prior to the final administration and at 0.16,0.33,0.50,0.75,1,1.5,2,4,8,12 and 24 h post-final administration.The plasma concentration of rivaroxaban in rats was determined by high-performance liquid chromatography-tandem mass spectrometry.The pharmacokinetic parameters[peak concentration(cmax),half-life(t1/2),area under the drug concentration time curve(AUC),mean residence time(MRT),clearance(CL),apparent volume of distribution(Vd)and peak time(tmax)]of each group were calculated using a non-compartmental model of MonolixSuite 2023R1 pharmacokinetic software.RESULTS Compared with rivaroxaban alone group,AUC₀₋ₜ and AUC0-∞ of rivaroxaban in rats were increased significantly in high-dose Tongxinluo capsules+rivaroxaban group(P＜0.05),while CL was decreased significantly(P＜0.05);t1/2 and MRT were shortened,tmax was extended,cmax was increased,while Vd was decreased,but there was no statistical significance(P＞0.05).CONCLUSIONS Rivaroxaban combined with Tongxinluo capsules significantly increases the plasma exposure of rivaroxaban in rats.Potential drug-drug interactions should be considered in clinical practice based on the co-administration conditions.关键词
利伐沙班/通心络胶囊/药代动力学/药物相互作用Key words
rivaroxaban/Tongxinluo capsules/pharmacokinetics/drug interaction分类
医药卫生引用本文复制引用
付国胜,沈杰,华杰凯,邵宇鹏,马文娜,刘伟,张建伟,常昕楠..通心络胶囊对利伐沙班在大鼠体内药代动力学的影响[J].中国药房,2025,36(23):2930-2934,5.基金项目
全国中药特色技术传承人才培训项目(No.国中医药人教函[2023]96号) （No.国中医药人教函[2023]96号）
上海市科技计划项目(No.24QA2709200) （No.24QA2709200）
河北省高等学校科学研究项目(No.QN2025437) （No.QN2025437）
河北手性药物技术创新中心开放课题项目(No.ZXJJ20240204) （No.ZXJJ20240204）
上海药学服务青年创新项目(No.SPAYXFW2025A15) （No.SPAYXFW2025A15）
