中国药理学通报2025，Vol.41Issue(12)：2201-2211,11.DOI:10.12360/CPB202503017
2015～2024年国家自然科学基金抗肿瘤药物药理研究领域项目申请资助情况和关注热点分析
Analysis of the Funding Status and Research Focus in Field of Anti-Tumor Drugs Pharmacology in Projects Funded byNational Natural Science Foundation of China from 2015 to 2024
摘要
Abstract
Aim To delineate the research hotspots in the National Natural Science Foundation of China(NS-FC)in the field of Anti-Tumor Drugs Pharmacology(application code H3505)from 2015 to 2024,and to identify common deficiencies in grant applications,with the aim of promoting high-quality development of original anti-tumor targets and innovative drug research in China.Methods We compiled NSFC data for 2015-2024 on General Program,Young Scientist Fund and Fund for Less Developed Regions in the field of Anti-Tumor Drugs Pharmacology,examining appli-cation and funding trends.A multidimensional analysis was conducted on project topics,disciplinary hot-spots,interdisciplinary integration,and the adoption of emerging technologies and methodologies.Results A total of 798 projects were funded,with direct alloca-tions of RMB 293.52 million.Funded research con-centrated on drug resistance,novel target discovery,immunotherapy,and the tumor microenvironment;key mechanisms included programmed cell death,immune checkpoints,and metabolic reprogramming;and ad-vanced approaches-microbiome and multi-omics inte-gration,organoid models,and AI-assisted target min-ing-were widely adopted.Unfunded proposals most often suffered from insufficient innovation,weak pre-liminary data,and poorly defined scientific questions.Conclusions Antitumor pharmacology in China has transitioned from nonspecific cytotoxic strategies to pre-cision,multi-modal approaches exemplified by nucleic acid drugs,immunotherapies,and multitarget inhibi-tors.Continued emphasis on original target discovery,mechanistic innovation,and interdisciplinary,technol-ogy-driven research will be critical to advancing the field.关键词
国家自然科学基金/药理学/抗肿瘤药物药理/项目分析/研究方向/科学问题Key words
national natural science foundation of chi-na/pharmacology/anti-tumor drugs pharmacology/a-nalysis of projects/research fields/scientific issue分类
医药卫生引用本文复制引用
刘悦,郑楠,韩立炜..2015～2024年国家自然科学基金抗肿瘤药物药理研究领域项目申请资助情况和关注热点分析[J].中国药理学通报,2025,41(12):2201-2211,11.基金项目
国家自然科学基金面上项目(No 82300906) （No 82300906）
宁夏自然科学基金项目(No 2024AAC05060) （No 2024AAC05060）
