中国药理学通报2025，Vol.41Issue(12)：2218-2225,8.DOI:10.12360/CPB202504130
中枢神经系统退行性病变中线粒体炎症损伤的研究进展
Research advances in mitochondrial inflammation-mediated damage in central nervous system degenerative disorders
摘要
Abstract
Central nervous system(CNS)degenerative disorders refer to a spectrum of pathological alterations triggered by struc-tural damage to cerebral neural tissues,clinically manifested as diverse neurological dysfunction syndromes,including multiple sclerosis(MS),neurodegenerative diseases(NDs),and ische-mic stroke.The hallmark pathological features of these disorders involve irreversible neuronal damage and decompensation of functional neural networks,ultimately leading to progressive neurological deficits.Notably,with the accelerating global popu-lation aging,the incidence of these diseases has surged signifi-cantly.According to WHO statistics,they now rank among the top three global causes of disability and mortality.Current re-search has confirmed that the pathogenesis of CNS degenerative disorders exhibits high heterogeneity,encompassing multifaceted pathophysiological processes such as genetic predisposition,oxi-dative stress,protein misfolding,and metabolic dysregulation.This intricate pathogenic network not only complicates clinical differential diagnosis but also poses substantial challenges to the development of precision therapeutic strategies.Importantly,re-cent studies have revealed that mitochondrial homeostasis disrup-tion-induced inflammatory cascades(termed mitochondrial in-flammation)play a pivotal regulatory role in neurodegenerative progression.Key molecular mechanisms include impaired mito-phagy,aberrant mitochondrial DNA(mtDNA)release and NL-RP3 inflammasome activation.This review systematically deci-phers the molecular regulatory network of mitochondrial inflam-mation,with a focus on its biological effects in critical pathologi-cal events such as blood-brain barrier disruption,microglial hy-peractivation and neuronal apoptosis.The overarching aim is to provide a theoretical foundation for developing innovative thera-peutic strategies targeting mitochondrial homeostasis restoration.关键词
中枢神经系统退行性病变/神经退行性疾病/线粒体炎症/线粒体DNA/活性氧/线粒体相关膜Key words
central nervous system degenerative disorders/neurodegenerative diseases/mitochondrial inflammation/mito-chondrial DNA/reactive oxygen species/mitochondria-associat-ed endoplasmic reticulum membranes分类
医药卫生引用本文复制引用
李淑琴,杨岩涛,艾启迪,陈乃宏,刘莎莎,颜倩,王汉隆,孙洋,黄艳婷,张浩杰,梁金萍,楚世峰..中枢神经系统退行性病变中线粒体炎症损伤的研究进展[J].中国药理学通报,2025,41(12):2218-2225,8.基金项目
国家自然科学基金资助项目(No 82130109,U2202214) （No 82130109,U2202214）
湖南省自然科学基金项目(No 2023JJ60471) （No 2023JJ60471）
湖南省中医药管理局科研课题一般项目(No B2024004) （No B2024004）
长沙市妇幼保健院2023年度院级院级科研重点项目(No 202329-2) （No 202329-2）
湖南中医药大学生物工程重点学科([2018]No 3) （[2018]No 3）
湖南中医药大学化学工程与技术一流学科建设项目 （）
湖南中医药大学中药学一流学科建设项目 （）
