中国药理学通报2025，Vol.41Issue(12)：2226-2230,5.DOI:10.12360/CPB2024
肿瘤相关成纤维细胞与巨噬细胞间通讯在肿瘤发展中的作用
Role of cell communication between cancer-associated fibroblasts and tumor-associated macrophages in tumor development
摘要
Abstract
Cancer-associated fibroblasts(CAFs)and tumor-asso-ciated macrophages(TAMs)play crucial roles in the tumor microenvironment,and their interaction exerts a significant influ-ence on tumorigenesis and development.With the rapid develop-ment of research techniques,we have acquired novel understand-ings of the cell communication between TAMs and CAFs at the single-cell level.The cell communication between the two is of-ten related to the polarization of TAMs and remodeling of the mi-croenvironmental matrix by CAFs,thereby mediating mechanisms such as immunosuppression or tumor invasion and metastasis.Specific subsets of CAFs and TAMs have also been discovered to play a role in suppressing tumor progression.Nutrient metabo-lites may also participate in the interaction between CAFs and TAMs and have the potential to become new therapeutic targets for tumors.This review explores the research progress in the cell communication between TAMs and CAFs,expounds on the com-plexity of their interaction,and is expected to provide new per-spectives for the treatment and prevention of cancer and tumors.关键词
肿瘤相关成纤维细胞/肿瘤相关巨噬细胞/细胞通讯/肿瘤微环境/免疫/作用机制Key words
cancer-associated fibroblasts/tumor-associated macrophages/cell communication/tumor microenvironment/immunity/mechanisms of action分类
医药卫生引用本文复制引用
邵祺晖,战智琰,洪莉..肿瘤相关成纤维细胞与巨噬细胞间通讯在肿瘤发展中的作用[J].中国药理学通报,2025,41(12):2226-2230,5.基金项目
国家重点研发计划(No 2023YFC2706505) （No 2023YFC2706505）
"科技创新行动计划"启明星项目(扬帆专项)(No 24YF2727200) （扬帆专项）
