中国药理学通报2025，Vol.41Issue(12)：2230-2235,6.DOI:10.12360/CPB202505059
基于表观遗传学探讨衰老的发生机制和干预策略
Mechanisms and intervention strategies of aging based on epigenetics
摘要
Abstract
Aging is comprehensively influenced by multiple fac-tors such as internal genes,cellular metabolism,external envi-ronment,and lifestyle habits.Among them,epigenetic regula-tion plays a core role.Epigenetic modifications,including DNA methylation,histone modification,heterochromatin remodeling,and non-coding RNA regulation,act in concert with the three-di-mensional genome architecture to precisely regulate gene expres-sion.This review elaborates on the factors influencing epigenetic regulation,as well as the mechanisms of how epigenetics affects the occurrence of organismal aging and the corresponding inter-vention strategies,providing relevant insights for uncovering the mechanisms of aging and preventing/treating aging-related disea-ses.关键词
表观遗传调控/衰老/DNA甲基化/组蛋白修饰/RNA修饰/三维基因组架构/熵变Key words
epigenetic regulation/aging/DNA methylation/histone modification/RNA modification/three-dimensional ge-nome architecture/entropy change分类
医药卫生引用本文复制引用
张丽媛,董世芬,史浩男,张文凤,张明倩,赵子阳,程真真,张体,闫振腾,孙建宁..基于表观遗传学探讨衰老的发生机制和干预策略[J].中国药理学通报,2025,41(12):2230-2235,6.基金项目
国家自然科学基金资助项目(No 81503287) （No 81503287）
北京市自然科学基金资助项目(No 7232287) （No 7232287）
