中国药理学通报2025，Vol.41Issue(12)：2240-2245,6.DOI:10.12360/CPB2504157
caspase-8依赖的细胞死亡方式与脑缺血/再灌注损伤
caspase-8-dependent cell death mode and cerebral ischemia/reperfusion injury
摘要
Abstract
Caspase-8 is a cysteine-aspartate protease widely dis-tributed in cells.As a molecular"switch",caspase-8 is involved in the regulation of various modes of cell death,including apopto-sis,necroptosis and pyroptosis.During cerebral ischemia/reper-fusion,caspase-8 activation is one of the key factors inducing neuronal cell death.Currently there are both specific inhibitors of caspase-8,such as Z-IETD-FMK and Ac-IETD-CHO,as well as a variety of pan-caspase inhibitors,such as z-VAD,Q-VD-OPH,and enricosan.Both animal and cellular experiments have demonstrated that all of these inhibitors attenuate cerebral ische-mia/reperfusion injury,an effect that involves inhibition of caspase-8 activity and reduction of neuronal apoptosis.Clinical-ly,certain drugs for ischemic stroke reduce plasma caspase-8 ac-tivity,suggesting that caspase-8 may be a biomarker for the diag-nosis and prognosis of ischemic stroke.Finding and developing clinically valuable inhibitors around caspase-8 is expected to provide new ideas for new drug development in ischemic stroke.关键词
caspase-8/caspase-8抑制剂/细胞凋亡/坏死样凋亡/细胞焦亡/脑缺血/再灌注Key words
caspase-8/caspase-8 inhibitor/apoptosis/necrop-tosis/pyroptosis/cerebral ischemia/reperfusion分类
医药卫生引用本文复制引用
车彦熹,罗秀菊,彭军..caspase-8依赖的细胞死亡方式与脑缺血/再灌注损伤[J].中国药理学通报,2025,41(12):2240-2245,6.基金项目
国家自然科学基金资助项目(N0 82173815,81872873) （N0 82173815,81872873）
